BDBM50289714 1H-Indole-2-carboxylic acid [(S)-1-((1S,2S,4S)-1-cyclohexylmethyl-2,4-dihydroxy-5-methyl-hexylcarbamoyl)-2-(1H-imidazol-4-yl)-ethyl]-amide::CHEMBL54677

SMILES CC(C)[C@@H](O)C[C@H](O)[C@H](CC1CCCCC1)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)c1cc2ccccc2[nH]1

InChI Key InChIKey=WOVROQCAJRMPKP-UHFFFAOYSA-N

Data  8 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 50289714   

TargetRenin(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50289714(1H-Indole-2-carboxylic acid [(S)-1-((1S,2S,4S)-1-c...)
Affinity DataIC50: 42nMAssay Description:In vitro renin inhibitory effect was evaluated for plasma renin activity (PRA) of marmoset plasma renin, Expressed as IC50More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/21/2010
Entry Details Article

TargetCathepsin D(Bovine)
TBA

Curated by ChEMBL
LigandPNGBDBM50289714(1H-Indole-2-carboxylic acid [(S)-1-((1S,2S,4S)-1-c...)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibitory activity against cathepsin D (bovine), expressed as IC50More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/21/2010
Entry Details Article

TargetRenin(Rat)
TBA

Curated by ChEMBL
LigandPNGBDBM50289714(1H-Indole-2-carboxylic acid [(S)-1-((1S,2S,4S)-1-c...)
Affinity DataIC50: 1.00E+5nMAssay Description:In vitro renin inhibitory effect was evaluated for plasma renin activity (PRA) of rat plasma renin, Expressed as IC50More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/21/2010
Entry Details Article

TargetPepsin A(Pig)
TBA

Curated by ChEMBL
LigandPNGBDBM50289714(1H-Indole-2-carboxylic acid [(S)-1-((1S,2S,4S)-1-c...)
Affinity DataIC50: 1.00E+5nMAssay Description:In vitro inhibitory effect was evaluated against pepsin, Expressed as IC50More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/21/2010
Entry Details Article

TargetAngiotensin-converting enzyme(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50289714(1H-Indole-2-carboxylic acid [(S)-1-((1S,2S,4S)-1-c...)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibitory activity against ACE human, expressed as IC50More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/21/2010
Entry Details Article

TargetRenin(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50289714(1H-Indole-2-carboxylic acid [(S)-1-((1S,2S,4S)-1-c...)
Affinity DataIC50: 3.50E+3nMAssay Description:In vitro renin inhibitory effect was evaluated for plasma renin activity (PRA) of dog plasma renin, Expressed as IC50More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/21/2010
Entry Details Article

TargetRenin(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50289714(1H-Indole-2-carboxylic acid [(S)-1-((1S,2S,4S)-1-c...)
Affinity DataIC50: 45nMAssay Description:In vitro renin inhibitory effect was evaluated for plasma renin activity (PRA) of human plasma, Expressed as IC50More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/21/2010
Entry Details Article

TargetRenin(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50289714(1H-Indole-2-carboxylic acid [(S)-1-((1S,2S,4S)-1-c...)
Affinity DataIC50: 93nMAssay Description:In vitro renin inhibitory effect was evaluated for plasma renin activity (PRA) of monkey plasma, Expressed as IC50More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/21/2010
Entry Details Article