BDBM502898 (2R,6S)-4-(5-cyanopyrimidin-2-yl)-N-(2-{1-[(4- fluorophenyl)methyl]-piperidin-4-yl}ethyl)-2,6- dimethylpiperazine-1-carboxamide::US11033539, Cpd. No. 6-48

SMILES C[C@H]1CN(C[C@@H](C)N1C(=O)NCCC1CCN(Cc2ccc(F)cc2)CC1)c1ncc(cn1)C#N

InChI Key InChIKey=ZGOFUOAOPMQRJC-UHFFFAOYSA-N

Data  5 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 502898   

TargetMuscarinic acetylcholine receptor M4(Human)
Neurocrine Biosciences

US Patent
LigandPNGBDBM502898(US11033539, Cpd. No. 6-48 | (2R,6S)-4-(5-cyanopyri...)
Affinity DataKi: <10nMAssay Description:Binding affinity (Ki) of compounds was measured by inhibition of radioligand binding to membranes from CHO cells expressing human M1, M2, M3, M4 and ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/5/2021
Entry Details
US Patent

TargetMuscarinic acetylcholine receptor M2(Human)
Neurocrine Biosciences

US Patent
LigandPNGBDBM502898(US11033539, Cpd. No. 6-48 | (2R,6S)-4-(5-cyanopyri...)
Affinity DataKi:  55nMAssay Description:Binding affinity (Ki) of compounds was measured by inhibition of radioligand binding to membranes from CHO cells expressing human M1, M2, M3, M4 and ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/5/2021
Entry Details
US Patent

TargetMuscarinic acetylcholine receptor M1(Human)
Neurocrine Biosciences

US Patent
LigandPNGBDBM502898(US11033539, Cpd. No. 6-48 | (2R,6S)-4-(5-cyanopyri...)
Affinity DataKi: >100nMAssay Description:Binding affinity (Ki) of compounds was measured by inhibition of radioligand binding to membranes from CHO cells expressing human M1, M2, M3, M4 and ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/5/2021
Entry Details
US Patent

TargetMuscarinic acetylcholine receptor M3(Human)
Neurocrine Biosciences

US Patent
LigandPNGBDBM502898(US11033539, Cpd. No. 6-48 | (2R,6S)-4-(5-cyanopyri...)
Affinity DataKi: >100nMAssay Description:Binding affinity (Ki) of compounds was measured by inhibition of radioligand binding to membranes from CHO cells expressing human M1, M2, M3, M4 and ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/5/2021
Entry Details
US Patent

TargetMuscarinic acetylcholine receptor M5(Human)
Neurocrine Biosciences

US Patent
LigandPNGBDBM502898(US11033539, Cpd. No. 6-48 | (2R,6S)-4-(5-cyanopyri...)
Affinity DataKi: >100nMAssay Description:Binding affinity (Ki) of compounds was measured by inhibition of radioligand binding to membranes from CHO cells expressing human M1, M2, M3, M4 and ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/5/2021
Entry Details
US Patent