BDBM502900 (2R,6S)-N-{2-[1-(1H-indol-5-ylmethyl)piperidin-4-yl]ethyl}-2,6- dimethyl-4-[2-(trifluoromethyl)pyrimidin-5-yl]piperazine-1- carboxamide::US11033539, Cpd. No. 6-50

SMILES C[C@H]1CN(C[C@@H](C)N1C(=O)NCCC1CCN(Cc2ccc3[nH]ccc3c2)CC1)c1cnc(nc1)C(F)(F)F

InChI Key InChIKey=KSYASPKMYHOTJG-UHFFFAOYSA-N

Data  5 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 502900   

TargetMuscarinic acetylcholine receptor M4(Human)
Neurocrine Biosciences

US Patent
LigandPNGBDBM502900(US11033539, Cpd. No. 6-50 | (2R,6S)-N-{2-[1-(1H-in...)
Affinity DataKi: <10nMAssay Description:Binding affinity (Ki) of compounds was measured by inhibition of radioligand binding to membranes from CHO cells expressing human M1, M2, M3, M4 and ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/5/2021
Entry Details
US Patent

TargetMuscarinic acetylcholine receptor M2(Human)
Neurocrine Biosciences

US Patent
LigandPNGBDBM502900(US11033539, Cpd. No. 6-50 | (2R,6S)-N-{2-[1-(1H-in...)
Affinity DataKi:  55nMAssay Description:Binding affinity (Ki) of compounds was measured by inhibition of radioligand binding to membranes from CHO cells expressing human M1, M2, M3, M4 and ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/5/2021
Entry Details
US Patent

TargetMuscarinic acetylcholine receptor M5(Human)
Neurocrine Biosciences

US Patent
LigandPNGBDBM502900(US11033539, Cpd. No. 6-50 | (2R,6S)-N-{2-[1-(1H-in...)
Affinity DataKi: >100nMAssay Description:Binding affinity (Ki) of compounds was measured by inhibition of radioligand binding to membranes from CHO cells expressing human M1, M2, M3, M4 and ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/5/2021
Entry Details
US Patent

TargetMuscarinic acetylcholine receptor M1(Human)
Neurocrine Biosciences

US Patent
LigandPNGBDBM502900(US11033539, Cpd. No. 6-50 | (2R,6S)-N-{2-[1-(1H-in...)
Affinity DataKi:  550nMAssay Description:Binding affinity (Ki) of compounds was measured by inhibition of radioligand binding to membranes from CHO cells expressing human M1, M2, M3, M4 and ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/5/2021
Entry Details
US Patent

TargetMuscarinic acetylcholine receptor M3(Human)
Neurocrine Biosciences

US Patent
LigandPNGBDBM502900(US11033539, Cpd. No. 6-50 | (2R,6S)-N-{2-[1-(1H-in...)
Affinity DataKi:  550nMAssay Description:Binding affinity (Ki) of compounds was measured by inhibition of radioligand binding to membranes from CHO cells expressing human M1, M2, M3, M4 and ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/5/2021
Entry Details
US Patent