BDBM50290142 CHEMBL3745838

SMILES CC(=O)NC1CCN(CC1)c1nc(nc2CCN(Cc3ccc(Cl)cc3)Cc12)-c1ccccn1

InChI Key InChIKey=IDLZDNFSWJZNPK-UHFFFAOYSA-N

Data  3 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50290142   

LigandPNGBDBM50290142(CHEMBL3745838)
Affinity DataEC50:  700nMAssay Description:Corrector activity at human CFTR F508 deletion mutant expressed in FRT cells incubated for 25 mins with forskolin by YFP-based fluorescence analysis ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2020
Entry Details Article
PubMed
LigandPNGBDBM50290142(CHEMBL3745838)
Affinity DataEC50:  708nMAssay Description:Corrector activity at CFTR F508-del mutant (unknown origin) expressed in human CFBE41o cells harboring HS-YFP preincubated for 24 hrs followed by for...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/28/2020
Entry Details Article
PubMed
LigandPNGBDBM50290142(CHEMBL3745838)
Affinity DataEC50:  1.90E+3nMAssay Description:Corrector activity at human CFTR F508 deletion mutant expressed in human A549 cells incubated for 25 mins by YFP-based fluorescence analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2020
Entry Details Article
PubMed