BDBM50290151 CHEMBL531405::TCMDC-132109

SMILES COc1ccc(cc1)-c1nc2c(N)nc(N)nc2nc1C(C)C

InChI Key InChIKey=JSBOSQNHHOBMRZ-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50290151   

TargetDihydrofolate reductase(Human)
National University of Singapore

Curated by ChEMBL
LigandPNGBDBM50290151(CHEMBL531405 | TCMDC-132109)
Affinity DataIC50: 382nMAssay Description:Inhibition of human DHFR assessed as reduction in consumption of NADPH using DHF as substrate by fluorescence methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/28/2020
Entry Details Article
PubMed
TargetDihydrofolate reductase(Mycobacterium tuberculosis (strain ATCC 25618 / H3...)
National University of Singapore

Curated by ChEMBL
LigandPNGBDBM50290151(CHEMBL531405 | TCMDC-132109)
Affinity DataIC50: 55nMAssay Description:Inhibition of Mycobacterium tuberculosis H37Rv DHFR expressed in Escherichia coli assessed as reduction in consumption of NADPH using DHF as substrat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/28/2020
Entry Details Article
PubMed