BDBM50291208 CHEMBL4175829

SMILES CCc1nc2c(ccnc2n1Cc1cccc(F)c1)N1CCNCC1

InChI Key InChIKey=VVFMFUGAHRAYJX-UHFFFAOYSA-N

Data  6 KI  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 50291208   

Target5-hydroxytryptamine receptor 6(Human)
Palack£

Curated by ChEMBL
LigandPNGBDBM50291208(CHEMBL4175829)
Affinity DataIC50: 18nMAssay Description:Antagonist activity at 5HT6R (unknown origin) transfected in NG108-15 cells co-transfected with CAMYEL assessed as reduction in cAMP levels after 5 m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/29/2020
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 6(Human)
Palack£

Curated by ChEMBL
LigandPNGBDBM50291208(CHEMBL4175829)
Affinity DataIC50: 18nMAssay Description:Partial inverse agonist activity at 5HT6R (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2022
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 6(Human)
Palack£

Curated by ChEMBL
LigandPNGBDBM50291208(CHEMBL4175829)
Affinity DataKi:  6nMAssay Description:Displacement of [3H]-LSD from human 5HT6R expressed in HEK293 cell membranes after 1 hr by microbeta counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/29/2020
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 6(Human)
Palack£

Curated by ChEMBL
LigandPNGBDBM50291208(CHEMBL4175829)
Affinity DataKi:  6nMAssay Description:Binding affinity to 5HT6R (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2022
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2A(Human)
Palack£

Curated by ChEMBL
LigandPNGBDBM50291208(CHEMBL4175829)
Affinity DataKi:  441nMAssay Description:Displacement of [3H]-Ketanserin from human 5HT2AR expressed in CHO-K1 cell membranes after 1.5 hrs by microbeta counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/29/2020
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 1A(Human)
Palack£

Curated by ChEMBL
LigandPNGBDBM50291208(CHEMBL4175829)
Affinity DataKi:  2.79E+3nMAssay Description:Displacement of [3H]-8-OH-DPAT from human 5HT1AR expressed in HEK293 cell membranes after 1 hr by microbeta counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/29/2020
Entry Details Article
PubMed
TargetD(2) dopamine receptor(Human)
Palack£

Curated by ChEMBL
LigandPNGBDBM50291208(CHEMBL4175829)
Affinity DataKi:  3.48E+3nMAssay Description:Displacement of [3H]-Raclopride from human dopamine D2L receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/29/2020
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 7(Human)
Palack£

Curated by ChEMBL
LigandPNGBDBM50291208(CHEMBL4175829)
Affinity DataKi:  1.23E+4nMAssay Description:Displacement of [3H]-5-CT from human 5HT7BR expressed in HEK293 cell membranes after 1 hr by microbeta counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/29/2020
Entry Details Article
PubMed