BDBM50291300 CHEMBL4168752

SMILES [#6]\[#6](-[#6])=[#6]\[#6@H]-1-[#8]-c2cc(-[#8])ccc2-c2oc3c4-[#6]=[#6]C([#6])([#6])[#8]-c4cc(-[#8])c3c(=O)c12

InChI Key InChIKey=CNSTWFCIWOBGDU-UHFFFAOYSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50291300   

TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4D(Human)
Sun Yat-Sen University

Curated by ChEMBL
LigandPNGBDBM50291300(CHEMBL4168752)
Affinity DataIC50: 5.40nMAssay Description:Inhibition of human PDE4D2 catalytic domain (86 to 413 residues) expressed in Escherichia coli strain BL21 using [3H]cAMP as substrate after 15 mins ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/30/2020
Entry Details Article
PubMed
LigandPNGBDBM50291300(CHEMBL4168752)
Affinity DataIC50: 300nMAssay Description:Inhibition of human PDE1B2 catalytic domain (10 to 487 residues) expressed in Escherichia coli strain BL21 using [3H]cAMP as substrate after 15 mins ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/30/2020
Entry Details Article
PubMed
TargetHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A(Human)
Sun Yat-Sen University

Curated by ChEMBL
LigandPNGBDBM50291300(CHEMBL4168752)
Affinity DataIC50: 350nMAssay Description:Inhibition of human PDE9A2 catalytic domain (181 to 506 residues) expressed in Escherichia coli strain BL21 using [3H]cAMP as substrate after 15 mins...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/30/2020
Entry Details Article
PubMed
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Human)
Sun Yat-Sen University

Curated by ChEMBL
LigandPNGBDBM50291300(CHEMBL4168752)
Affinity DataIC50: 410nMAssay Description:Inhibition of human PDE5A1 catalytic domain (535 to 860 residues) expressed in Escherichia coli strain BL21 using [3H]cAMP as substrate after 15 mins...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/30/2020
Entry Details Article
PubMed
TargetcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A(Human)
Sun Yat-Sen University

Curated by ChEMBL
LigandPNGBDBM50291300(CHEMBL4168752)
Affinity DataIC50: 510nMAssay Description:Inhibition of human PDE10A2 catalytic domain (448 to 789 residues) expressed in Escherichia coli strain BL21 using [3H]cAMP as substrate after 15 min...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/30/2020
Entry Details Article
PubMed
TargetcGMP-dependent 3',5'-cyclic phosphodiesterase(Human)
Sun Yat-Sen University

Curated by ChEMBL
LigandPNGBDBM50291300(CHEMBL4168752)
Affinity DataIC50: 590nMAssay Description:Inhibition of human PDE2A3 catalytic domain (222 to 904 residues) expressed in Escherichia coli strain BL21 using [3H]cAMP as substrate after 15 mins...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/30/2020
Entry Details Article
PubMed