BDBM50291417 (E)-3-((S)-4-Ethyl-4-hydroxy-3,13-dioxo-3,4,12,13-tetrahydro-1H-2-oxa-6,12a-diaza-dibenzo[b,h]fluoren-10-yl)-acrylamide::CHEMBL413917

SMILES CC[C@@]1(O)C(=O)OCc2c1cc1-c3nc4cccc(\C=C\C(N)=O)c4cc3Cn1c2=O

InChI Key InChIKey=XAJPAHVOFGXQGH-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50291417   

TargetDNA topoisomerase 1(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50291417((E)-3-((S)-4-Ethyl-4-hydroxy-3,13-dioxo-3,4,12,13-...)
Affinity DataIC50: 3.20E+3nMAssay Description:Concentration required to inhibit 50% relaxation of 250 ng of SV40 DNA obtained with 0.5 I.U topoisomerase I at 37 degrees C for 30 minMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2010
Entry Details Article