BDBM50291702 (3-Hydroxycarbamoyl-3,4-dihydro-1H-isoquinolin-2-yl)-(4-methoxy-phenyl)-phosphinic acid 2,2-difluoro-ethyl ester::(R)-((R)-3-Hydroxycarbamoyl-3,4-dihydro-1H-isoquinolin-2-yl)-(4-methoxy-phenyl)-phosphinic acid 2,2-difluoro-ethyl ester::CHEMBL435462

SMILES COc1ccc(cc1)[P@](=O)(OCC(F)F)N1Cc2ccccc2C[C@@H]1C(=O)NO

InChI Key InChIKey=YYRRVFYCIQQYHU-UHFFFAOYSA-N

Data  9 KI  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 11 hits for monomerid = 50291702   

LigandPNGBDBM50291702((R)-((R)-3-Hydroxycarbamoyl-3,4-dihydro-1H-isoquin...)
Affinity DataIC50: 510nMAssay Description:Inhibition of heparin-binding epidermal growth factor (HB-EGF) sheddingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetAmphiregulin(Human)
Organon K.K.

Curated by ChEMBL
LigandPNGBDBM50291702((R)-((R)-3-Hydroxycarbamoyl-3,4-dihydro-1H-isoquin...)
Affinity DataIC50: 1.47E+3nMAssay Description:In vitro amphiregulin shedding inhibitionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMatrix metalloproteinase-9(Human)
Organon K.K.

Curated by ChEMBL
LigandPNGBDBM50291702((R)-((R)-3-Hydroxycarbamoyl-3,4-dihydro-1H-isoquin...)
Affinity DataKi:  5nMAssay Description:Inhibition of Matrix metalloprotease-9 (MMP-9)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMatrix metalloproteinase-9(Human)
Organon K.K.

Curated by ChEMBL
LigandPNGBDBM50291702((R)-((R)-3-Hydroxycarbamoyl-3,4-dihydro-1H-isoquin...)
Affinity DataKi:  5nMAssay Description:Inhibitory constant against recombinant human gelatinase B (Matrix metalloprotease-9)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetInterstitial collagenase(Human)
Organon K.K.

Curated by ChEMBL
LigandPNGBDBM50291702((R)-((R)-3-Hydroxycarbamoyl-3,4-dihydro-1H-isoquin...)
Affinity DataKi:  6nMAssay Description:Inhibition of Matrix metalloprotease-1 (MMP-1)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetInterstitial collagenase(Human)
Organon K.K.

Curated by ChEMBL
LigandPNGBDBM50291702((R)-((R)-3-Hydroxycarbamoyl-3,4-dihydro-1H-isoquin...)
Affinity DataKi:  6nMAssay Description:Inhibitory constant against recombinant human Matrix metalloprotease-1More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetStromelysin-1(Human)
Organon K.K.

Curated by ChEMBL
LigandPNGBDBM50291702((R)-((R)-3-Hydroxycarbamoyl-3,4-dihydro-1H-isoquin...)
Affinity DataKi:  6.70nMAssay Description:Inhibition of Matrix metalloprotease-3 (MMP-3)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetStromelysin-1(Human)
Organon K.K.

Curated by ChEMBL
LigandPNGBDBM50291702((R)-((R)-3-Hydroxycarbamoyl-3,4-dihydro-1H-isoquin...)
Affinity DataKi:  6.70nMAssay Description:Inhibitory constant against recombinant human stromelysin-1 (Matrix metalloprotease-3)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetInterstitial collagenase(Human)
Organon K.K.

Curated by ChEMBL
LigandPNGBDBM50291702((R)-((R)-3-Hydroxycarbamoyl-3,4-dihydro-1H-isoquin...)
Affinity DataKi:  125nMAssay Description:Inhibitory constant against recombinant human Matrix metalloprotease-1More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMatrix metalloproteinase-9(Human)
Organon K.K.

Curated by ChEMBL
LigandPNGBDBM50291702((R)-((R)-3-Hydroxycarbamoyl-3,4-dihydro-1H-isoquin...)
Affinity DataKi:  483nMAssay Description:Inhibitory constant against recombinant human gelatinase B (Matrix metalloprotease-9)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetStromelysin-1(Human)
Organon K.K.

Curated by ChEMBL
LigandPNGBDBM50291702((R)-((R)-3-Hydroxycarbamoyl-3,4-dihydro-1H-isoquin...)
Affinity DataKi: >650nMAssay Description:Inhibitory constant against recombinant human stromelysin-1 (Matrix metalloprotease-3)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed