BDBM50292577 CHEMBL4161938

SMILES Fc1cccc(COc2ccc(Nc3ncnc4cc(OCCCN5CCOCC5)c(OCCCN5CCOCC5)cc34)cc2Cl)c1

InChI Key InChIKey=WKIZAFVIMHRRPF-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50292577   

TargetEpidermal growth factor receptor(Human)
Shaanxi Normal University

Curated by ChEMBL
LigandPNGBDBM50292577(CHEMBL4161938)
Affinity DataIC50: 7nMAssay Description:Inhibition of recombinant human N-terminal His-tagged EGFR (1 to 645 residues) expressed in HEK293 cells by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/9/2020
Entry Details Article
PubMed
TargetEpidermal growth factor receptor(Human)
Shaanxi Normal University

Curated by ChEMBL
LigandPNGBDBM50292577(CHEMBL4161938)
Affinity DataIC50: 9.30nMAssay Description:Inhibition of EGFR T790M mutant (unknown origin) preincubated for 10 mins followed by TK substrate-botion addition measured after 1 hr by spectrophot...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/9/2020
Entry Details Article
PubMed
TargetEpidermal growth factor receptor(Human)
Shaanxi Normal University

Curated by ChEMBL
LigandPNGBDBM50292577(CHEMBL4161938)
Affinity DataIC50: 323nMAssay Description:Inhibition of EGFR L858R mutant (unknown origin) using ULight-poly GT as substrate preincubated for 120 mins followed by substrate addition measured ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/9/2020
Entry Details Article
PubMed
TargetEpidermal growth factor receptor(Human)
Shaanxi Normal University

Curated by ChEMBL
LigandPNGBDBM50292577(CHEMBL4161938)
Affinity DataIC50: 2.00E+3nMAssay Description:Inhibition of EGFR L858R/T790M double mutant (unknown origin) using ULight-poly GT as substrate preincubated for 30 mins followed by substrate additi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/9/2020
Entry Details Article
PubMed