BDBM502934 (2R)-N-[(2R)-2-(1-benzylpiperidin-4-yl)-2-hydroxyethyl]-4-[3- cyano-4-(trifluoromethoxy)phenyl]-2-methylpiperazine-1-carboxamide::US11033539, Cpd. No. 7-10

SMILES C[C@@H]1CN(CCN1C(=O)NC[C@H](O)C1CCN(Cc2ccccc2)CC1)c1ccc(OC(F)(F)F)c(c1)C#N

InChI Key InChIKey=BWRANTVGWDIQCH-UHFFFAOYSA-N

Data  5 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 502934   

TargetMuscarinic acetylcholine receptor M4(Human)
Neurocrine Biosciences

US Patent
LigandPNGBDBM502934(US11033539, Cpd. No. 7-10 | (2R)-N-[(2R)-2-(1-benz...)
Affinity DataKi: <10nMAssay Description:Binding affinity (Ki) of compounds was measured by inhibition of radioligand binding to membranes from CHO cells expressing human M1, M2, M3, M4 and ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/5/2021
Entry Details
US Patent

TargetMuscarinic acetylcholine receptor M1(Human)
Neurocrine Biosciences

US Patent
LigandPNGBDBM502934(US11033539, Cpd. No. 7-10 | (2R)-N-[(2R)-2-(1-benz...)
Affinity DataKi: >100nMAssay Description:Binding affinity (Ki) of compounds was measured by inhibition of radioligand binding to membranes from CHO cells expressing human M1, M2, M3, M4 and ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/5/2021
Entry Details
US Patent

TargetMuscarinic acetylcholine receptor M3(Human)
Neurocrine Biosciences

US Patent
LigandPNGBDBM502934(US11033539, Cpd. No. 7-10 | (2R)-N-[(2R)-2-(1-benz...)
Affinity DataKi: >100nMAssay Description:Binding affinity (Ki) of compounds was measured by inhibition of radioligand binding to membranes from CHO cells expressing human M1, M2, M3, M4 and ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/5/2021
Entry Details
US Patent

TargetMuscarinic acetylcholine receptor M5(Human)
Neurocrine Biosciences

US Patent
LigandPNGBDBM502934(US11033539, Cpd. No. 7-10 | (2R)-N-[(2R)-2-(1-benz...)
Affinity DataKi: >100nMAssay Description:Binding affinity (Ki) of compounds was measured by inhibition of radioligand binding to membranes from CHO cells expressing human M1, M2, M3, M4 and ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/5/2021
Entry Details
US Patent

TargetMuscarinic acetylcholine receptor M2(Human)
Neurocrine Biosciences

US Patent
LigandPNGBDBM502934(US11033539, Cpd. No. 7-10 | (2R)-N-[(2R)-2-(1-benz...)
Affinity DataKi:  550nMAssay Description:Binding affinity (Ki) of compounds was measured by inhibition of radioligand binding to membranes from CHO cells expressing human M1, M2, M3, M4 and ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/5/2021
Entry Details
US Patent