BDBM50294764 3,3-Dimethyl-pentanedioic acid cyclopropylamide(5-hydroxy-adamantan-2-yl)-amide::CHEMBL550424

SMILES CC(C)(CC(=O)NC1CC1)CC(=O)N[C@H]1C2CC3CC1C[C@](O)(C3)C2

InChI Key

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50294764   

Target11-beta-hydroxysteroid dehydrogenase 1(Human)
Merck Serono

Curated by ChEMBL
LigandPNGBDBM50294764(3,3-Dimethyl-pentanedioic acid cyclopropylamide(5-...)
Affinity DataIC50: 8nMAssay Description:Inhibition of human recombinant 11beta-HSD1 expressed in Escherichia coli assessed as cortisol level after 150 mins by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/26/2010
Entry Details Article
PubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Mouse)
Merck Serono

Curated by ChEMBL
LigandPNGBDBM50294764(3,3-Dimethyl-pentanedioic acid cyclopropylamide(5-...)
Affinity DataIC50: 88nMAssay Description:Inhibition of 11beta-HSD1 in mouse liver microsomeMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/26/2010
Entry Details Article
PubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Rat)
Merck Serono

Curated by ChEMBL
LigandPNGBDBM50294764(3,3-Dimethyl-pentanedioic acid cyclopropylamide(5-...)
Affinity DataIC50: 980nMAssay Description:Inhibition of 11beta-HSD1 in rat liver microsomeMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/26/2010
Entry Details Article
PubMed
Target11-beta-hydroxysteroid dehydrogenase type 2(Human)
Merck Serono

Curated by ChEMBL
LigandPNGBDBM50294764(3,3-Dimethyl-pentanedioic acid cyclopropylamide(5-...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human recombinant 11beta-HSD2 expressed in Escherichia coli assessed as cortisol level after 60 mins by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/26/2010
Entry Details Article
PubMed