BDBM50295539 4-(benzo[d]oxazol-2-yl)-N-(2-phenylcyclopropyl)piperidine-1-carboxamide::CHEMBL552402

SMILES O=C(NC1CC1c1ccccc1)N1CCC(CC1)c1nc2ccccc2o1

InChI Key InChIKey=SJIHFYQHTFWHTM-UHFFFAOYSA-N

Data  9 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 9 hits for monomerid = 50295539   

TargetBifunctional epoxide hydrolase 2(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50295539(4-(benzo[d]oxazol-2-yl)-N-(2-phenylcyclopropyl)pip...)
Affinity DataIC50: 7.5nMAssay Description:Inhibition of human sEHMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/24/2012
Entry Details Article
PubMed
TargetBifunctional epoxide hydrolase 2(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50295539(4-(benzo[d]oxazol-2-yl)-N-(2-phenylcyclopropyl)pip...)
Affinity DataIC50: 8nMAssay Description:Inhibition of human sEH in HEK293 cells assessed as conversion of 14,15-epoxyeicosatrienoic acid to 14,15-dihydroepoxyeicosatrienoic acidMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/24/2012
Entry Details Article
PubMed
TargetBifunctional epoxide hydrolase 2(Rat)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50295539(4-(benzo[d]oxazol-2-yl)-N-(2-phenylcyclopropyl)pip...)
Affinity DataIC50: 16nMAssay Description:Inhibition of rat sEHMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/24/2012
Entry Details Article
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50295539(4-(benzo[d]oxazol-2-yl)-N-(2-phenylcyclopropyl)pip...)
Affinity DataIC50: 8.20E+3nMAssay Description:Inhibition of IKr channelMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/24/2012
Entry Details Article
PubMed
TargetCytochrome P450 2D6(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50295539(4-(benzo[d]oxazol-2-yl)-N-(2-phenylcyclopropyl)pip...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of CYP2D6More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/24/2012
Entry Details Article
PubMed
TargetCytochrome P450 3A4(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50295539(4-(benzo[d]oxazol-2-yl)-N-(2-phenylcyclopropyl)pip...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of CYP3A4More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/24/2012
Entry Details Article
PubMed
TargetSodium channel protein type 5 subunit alpha(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50295539(4-(benzo[d]oxazol-2-yl)-N-(2-phenylcyclopropyl)pip...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of Nav1.5 channelMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/24/2012
Entry Details Article
PubMed
TargetVoltage-dependent L-type calcium channel subunit alpha-1C(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50295539(4-(benzo[d]oxazol-2-yl)-N-(2-phenylcyclopropyl)pip...)
Affinity DataIC50: 1.20E+4nMAssay Description:Inhibition of Cav 1.2 channelMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/24/2012
Entry Details Article
PubMed
TargetEpoxide hydrolase 1(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50295539(4-(benzo[d]oxazol-2-yl)-N-(2-phenylcyclopropyl)pip...)
Affinity DataIC50: 6.70E+4nMAssay Description:Inhibition of human mEHMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/24/2012
Entry Details Article
PubMed