BDBM50296915 (1S,3R)-N-((1-(3,5-difluorophenyl)-5-isopropyl-2-methyl-1H-imidazol-4-yl)methyl)-3-fluorocyclopentanamine::CHEMBL556300

SMILES CC(C)c1c(CN[C@H]2CC[C@@H](F)C2)nc(C)n1-c1cc(F)cc(F)c1

InChI Key InChIKey=WXGFDISGDAGZCW-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50296915   

TargetNociceptin receptor(Human)
Banyu Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50296915((1S,3R)-N-((1-(3,5-difluorophenyl)-5-isopropyl-2-m...)
Affinity DataIC50: 8.60nMAssay Description:Displacement of [125I]Tyr14-nociceptin from human ORL1 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/27/2010
Entry Details Article
PubMed
TargetNociceptin receptor(Human)
Banyu Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50296915((1S,3R)-N-((1-(3,5-difluorophenyl)-5-isopropyl-2-m...)
Affinity DataIC50: 4.5nMAssay Description:Antagonist activity at human cloned ORL1 receptor expressed in CHO cells assessed as inhibition of nociceptin/orphanin FQ-stimulated [35S]GTPgammaS b...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/27/2010
Entry Details Article
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Banyu Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50296915((1S,3R)-N-((1-(3,5-difluorophenyl)-5-isopropyl-2-m...)
Affinity DataIC50: 3.40E+4nMAssay Description:Displacement of [35S]MK499 from human ERG expressed in HEK293 cells overexpressing Ikr channel proteinMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/27/2010
Entry Details Article
PubMed