BDBM50297314 CHEMBL551413::N-Methyl-4-(spiro[chromene-2,4'-piperidine]-4-yl)benzamide

SMILES CNC(=O)c1ccc(cc1)C1=CC2(CCNCC2)Oc2ccccc12

InChI Key InChIKey=DJFRCGBULWFDHB-UHFFFAOYSA-N

Data  2 KI  2 IC50  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50297314   

TargetDelta-type opioid receptor(Human)
Adolor

Curated by ChEMBL
LigandPNGBDBM50297314(N-Methyl-4-(spiro[chromene-2,4'-piperidine]-4-yl)b...)
Affinity DataKi:  18nMAssay Description:Displacement of [3H]diprenorphine from human delta opioid receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/27/2010
Entry Details Article
PubMed
TargetDelta-type opioid receptor(Human)
Adolor

Curated by ChEMBL
LigandPNGBDBM50297314(N-Methyl-4-(spiro[chromene-2,4'-piperidine]-4-yl)b...)
Affinity DataEC50:  110nMAssay Description:Agonist activity at human delta opioid receptor expressed in CHO cells assessed as stimulation of [35S]GTPgammaS bindingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/27/2010
Entry Details Article
PubMed
TargetCytochrome P450 2D6(Human)
Adolor

Curated by ChEMBL
LigandPNGBDBM50297314(N-Methyl-4-(spiro[chromene-2,4'-piperidine]-4-yl)b...)
Affinity DataIC50: 1.20E+3nMAssay Description:Inhibition of human CYP2D6 by fluorescence-based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/27/2010
Entry Details Article
PubMed
TargetKappa-type opioid receptor(Human)
Adolor

Curated by ChEMBL
LigandPNGBDBM50297314(N-Methyl-4-(spiro[chromene-2,4'-piperidine]-4-yl)b...)
Affinity DataKi:  1.60E+3nMAssay Description:Displacement of [3H]diprenorphine from human kappa opioid receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/27/2010
Entry Details Article
PubMed
LigandPNGBDBM50297314(N-Methyl-4-(spiro[chromene-2,4'-piperidine]-4-yl)b...)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of human ERG channel expressed in HEK293 cells by voltage clamp assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/27/2010
Entry Details Article
PubMed