BDBM50297340 CHEMBL562478::N,N-Diethyl-3-methyl-4-(spiro[chromene-2,4'-piperidine]-4-yl)-benzamide

SMILES CCN(CC)C(=O)c1ccc(C2=CC3(CCNCC3)Oc3ccccc23)c(C)c1

InChI Key InChIKey=JXKIEMQPJWXXMU-UHFFFAOYSA-N

Data  3 KI  2 IC50  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50297340   

TargetDelta-type opioid receptor(Human)
Adolor

Curated by ChEMBL
LigandPNGBDBM50297340(N,N-Diethyl-3-methyl-4-(spiro[chromene-2,4'-piperi...)
Affinity DataKi:  2.40nMAssay Description:Displacement of [3H]diprenorphine from human delta opioid receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/27/2010
Entry Details Article
PubMed
TargetDelta-type opioid receptor(Human)
Adolor

Curated by ChEMBL
LigandPNGBDBM50297340(N,N-Diethyl-3-methyl-4-(spiro[chromene-2,4'-piperi...)
Affinity DataEC50:  360nMAssay Description:Agonist activity at human delta opioid receptor expressed in CHO cells assessed as stimulation of [35S]GTPgammaS bindingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/27/2010
Entry Details Article
PubMed
TargetKappa-type opioid receptor(Human)
Adolor

Curated by ChEMBL
LigandPNGBDBM50297340(N,N-Diethyl-3-methyl-4-(spiro[chromene-2,4'-piperi...)
Affinity DataKi:  390nMAssay Description:Displacement of [3H]diprenorphine from human kappa opioid receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/27/2010
Entry Details Article
PubMed
TargetMu-type opioid receptor(Human)
Adolor

Curated by ChEMBL
LigandPNGBDBM50297340(N,N-Diethyl-3-methyl-4-(spiro[chromene-2,4'-piperi...)
Affinity DataKi:  3.40E+3nMAssay Description:Displacement of [3H]diprenorphine from human mu opioid receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/27/2010
Entry Details Article
PubMed
LigandPNGBDBM50297340(N,N-Diethyl-3-methyl-4-(spiro[chromene-2,4'-piperi...)
Affinity DataIC50: 4.24E+3nMAssay Description:Inhibition of human ERG channel expressed in HEK293 cells by voltage clamp assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/27/2010
Entry Details Article
PubMed
TargetCytochrome P450 2D6(Human)
Adolor

Curated by ChEMBL
LigandPNGBDBM50297340(N,N-Diethyl-3-methyl-4-(spiro[chromene-2,4'-piperi...)
Affinity DataIC50: 4.60E+3nMAssay Description:Inhibition of human CYP2D6 by fluorescence-based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/27/2010
Entry Details Article
PubMed