BDBM50297825 5-(2-methyl-5-(3-(trifluoromethyl)phenylcarbamoyl)phenylamino)nicotinamide::5-[(2-Methyl-5-{[3- (trifluoromethyl)phenyl]carbamoyl}phenyl)amino]pyridine-3-carboxamide (1)::5-[(2-methyl-5-{[3-(trifluoromethyl)phenyl]carbamoyl}phenyl)amino]pyridine-3-carboxamide::CHEMBL552425

SMILES Cc1ccc(cc1Nc2cc(cnc2)C(=O)N)C(=O)Nc3cccc(c3)C(F)(F)F

InChI Key InChIKey=SAAYRHKJHDIDPH-UHFFFAOYSA-N

Data  5 IC50  2 EC50

PDB links: 1 PDB ID matches this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 50297825   

TargetDiscoidin domain-containing receptor 2(Human)
Dana-Farber Cancer Institute

LigandPNGBDBM50297825(5-[(2-methyl-5-{[3-(trifluoromethyl)phenyl]carbamo...)
Affinity DataIC50: 19nMAssay Description:The enzymatic activities SRC are tested in Z'-Lyte assays with ATP concentrations of Km (50 uM)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/16/2016
Entry Details Article
PubMed
TargetProto-oncogene tyrosine-protein kinase Src(Human)
Dana-Farber Cancer Institute

LigandPNGBDBM50297825(5-[(2-methyl-5-{[3-(trifluoromethyl)phenyl]carbamo...)
Affinity DataIC50: 753nMAssay Description:The enzymatic activities SRC are tested in Z'-Lyte assays with ATP concentrations of Km (50 uM)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/16/2016
Entry Details Article
PubMed
TargetEphrin type-B receptor 2(Human)
Institute

Curated by ChEMBL
LigandPNGBDBM50297825(5-[(2-methyl-5-{[3-(trifluoromethyl)phenyl]carbamo...)
Affinity DataEC50:  40nMAssay Description:Inhibition of EphB2More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/27/2010
Entry Details Article
PubMed
TargetEphrin type-B receptor 2(Human)
Institute

Curated by ChEMBL
LigandPNGBDBM50297825(5-[(2-methyl-5-{[3-(trifluoromethyl)phenyl]carbamo...)
Affinity DataEC50:  100nMAssay Description:Inhibition of ephrin-B1-induced autophosphorylation of EphB2 expressed in human U87 cells after 1 hr by Western blot analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/27/2010
Entry Details Article
PubMed
TargetDiscoidin domain-containing receptor 2(Human)
Dana-Farber Cancer Institute

LigandPNGBDBM50297825(5-[(2-methyl-5-{[3-(trifluoromethyl)phenyl]carbamo...)
Affinity DataIC50: 19nMAssay Description:Inhibition of kinase tracer 178 binding to recombinant human GST-tagged DDR2 (427-855 residues) expressed in baculovirus expression system incubated ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetEpithelial discoidin domain-containing receptor 1(Human)
Vanderbilt University

Curated by ChEMBL
LigandPNGBDBM50297825(5-[(2-methyl-5-{[3-(trifluoromethyl)phenyl]carbamo...)
Affinity DataIC50: 12nMAssay Description:Inhibition of kinase tracer 178 binding to recombinant human GST-tagged DDR1 expressed in baculovirus expression system incubated for 60 mins by TR-F...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetEpithelial discoidin domain-containing receptor 1(Human)
Vanderbilt University

Curated by ChEMBL
LigandPNGBDBM50297825(5-[(2-methyl-5-{[3-(trifluoromethyl)phenyl]carbamo...)
Affinity DataIC50: 4.80nMAssay Description:Inhibition of FLAG-tagged DDR1 in human HEK293 cells assessed as reduction in collagen-1-induced DDR1 phosphorylation incubated for 18 hrs by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed