BDBM50297854 1'-(1-(4-fluorobenzyl)-1H-benzo[d]imidazol-2-yl)-1,4'-bipiperidin-2-one::CHEMBL552026

SMILES Fc1ccc(Cn2c(nc3ccccc23)N2CCC(CC2)N2CCCCC2=O)cc1

InChI Key InChIKey=LUSFVKKEBIMJTI-UHFFFAOYSA-N

Data  2 KI  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50297854   

TargetHistamine H1 receptor(Human)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50297854(1'-(1-(4-fluorobenzyl)-1H-benzo[d]imidazol-2-yl)-1...)
Affinity DataKi:  6.60nMAssay Description:Displacement of [3H]pyrilamine from human histamine H1 receptor expressed in CHO Flp-In cells by liquid scintillation assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/27/2010
Entry Details Article
PubMed
TargetCytochrome P450 2D6(Human)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50297854(1'-(1-(4-fluorobenzyl)-1H-benzo[d]imidazol-2-yl)-1...)
Affinity DataIC50: 4.35E+3nMAssay Description:Inhibition of CYP2D6More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/27/2010
Entry Details Article
PubMed
TargetCytochrome P450 3A4(Human)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50297854(1'-(1-(4-fluorobenzyl)-1H-benzo[d]imidazol-2-yl)-1...)
Affinity DataIC50: 5.00E+3nMAssay Description:Inhibition of CYP3A4More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/27/2010
Entry Details Article
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50297854(1'-(1-(4-fluorobenzyl)-1H-benzo[d]imidazol-2-yl)-1...)
Affinity DataKi: >7.50E+3nMAssay Description:Displacement of [3H]dofetolide from human ERG channel expressed in HEK293 cells at 37 degC by liquid scintillation assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/27/2010
Entry Details Article
PubMed