BDBM50297948 3-[6-({[3-(2,6-Dichlorophenyl)-5-(1-methylethyl)-4-isoxazolyl]methyl}oxy)-1-oxo-3,4-dihydro-2(1H)-isoquinolinyl]benzoic acid::CHEMBL559950

SMILES CC(C)c1onc(c1COc1ccc2C(=O)N(CCc2c1)c1cccc(c1)C(O)=O)-c1c(Cl)cccc1Cl

InChI Key InChIKey=OKXAKDBWNJEFJW-UHFFFAOYSA-N

Data  2 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50297948   

TargetBile acid receptor(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50297948(3-[6-({[3-(2,6-Dichlorophenyl)-5-(1-methylethyl)-4...)
Affinity DataEC50:  710nMAssay Description:Induction of SRC1 coactivator peptide binding to ligand binding domain of human FXR by FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/27/2010
Entry Details Article
PubMed
TargetBile acid receptor(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50297948(3-[6-({[3-(2,6-Dichlorophenyl)-5-(1-methylethyl)-4...)
Affinity DataEC50:  8.30E+3nMAssay Description:Increase in human FXR-mediated transient transcription of luciferase reporter gene transfected in african green monkey CV1 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/27/2010
Entry Details Article
PubMed