BDBM50298804 (+/-)-6-methyl-5-(4-methyl-3-(3,4,5-trimethoxyphenyl)pent-1-ynyl)pyrimidine-2,4-diamine::CHEMBL582843

SMILES COc1cc(cc(OC)c1OC)C(C#Cc1c(C)nc(N)nc1N)C(C)C

InChI Key InChIKey=OHPJUBBWTNCBPF-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50298804   

TargetDihydrofolate reductase(Human)
University of Connecticut

Curated by ChEMBL
LigandPNGBDBM50298804((+/-)-6-methyl-5-(4-methyl-3-(3,4,5-trimethoxyphen...)
Affinity DataIC50: 290nMAssay Description:Inhibition of human DHFR assessed as rate of NADPH consumption using dihydrofolate as substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/29/2010
Entry Details Article
PubMed
TargetDihydrofolate reductase(Yeast)
University of Connecticut

Curated by ChEMBL
LigandPNGBDBM50298804((+/-)-6-methyl-5-(4-methyl-3-(3,4,5-trimethoxyphen...)
Affinity DataIC50: 33nMAssay Description:Inhibition of Candida albicans DHFR expressed in Escherichia coli BL21 (DE3) assessed as rate of NADPH consumption using dihydrofolate as substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/29/2010
Entry Details Article
PubMed