BDBM50299189 CHEMBL573421::N-(4-((2-chloro-5-(5-(methylsulfonyl)-1-(3-morpholinopropyl)-4,5,6,7-tetrahydro-1H-pyrazolo[4,3-c]pyridin-3-yl)phenyl)ethynyl)benzyl)benzenesulfonamide

SMILES CS(=O)(=O)N1CCc2c(C1)c(nn2CCCN1CCOCC1)-c1ccc(Cl)c(c1)C#Cc1ccc(CNS(=O)(=O)c2ccccc2)cc1

InChI Key InChIKey=BAKJPRTXUIRICM-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50299189   

TargetCathepsin S(Human)
Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL
LigandPNGBDBM50299189(N-(4-((2-chloro-5-(5-(methylsulfonyl)-1-(3-morphol...)
Affinity DataIC50: 160nMAssay Description:Inhibition of human recombinant cathepsin S expressed in baculovirus by FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/29/2010
Entry Details Article
PubMed
TargetCathepsin S(Human)
Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL
LigandPNGBDBM50299189(N-(4-((2-chloro-5-(5-(methylsulfonyl)-1-(3-morphol...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of cathepsin S in human JY cells assessed as invariant chain li degradation by Western blottingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/29/2010
Entry Details Article
PubMed