BDBM50299378 CHEMBL575340::N4-(2,3-dihydro-1H-inden-2-yl)-2-(piperazin-1-yl)-N6-(pyridin-4-yl)pyrimidine-4,6-diamine

SMILES C1C(Cc2ccccc12)Nc1cc(Nc2ccncc2)nc(n1)N1CCNCC1

InChI Key InChIKey=AMAAYJNDYUIOGC-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50299378   

TargetRho-associated protein kinase 1(Human)
Ligand Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50299378(N4-(2,3-dihydro-1H-inden-2-yl)-2-(piperazin-1-yl)-...)
Affinity DataIC50: 2nMAssay Description:Inhibition of ROCK1 by IMAP assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/29/2010
Entry Details Article
PubMed
TargetRho-associated protein kinase 1(Human)
Ligand Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50299378(N4-(2,3-dihydro-1H-inden-2-yl)-2-(piperazin-1-yl)-...)
Affinity DataIC50: 12nMAssay Description:Inhibition of ROCK1 in human THP1 cells assessed as inhibition of MCP1-induced cell migrationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/29/2010
Entry Details Article
PubMed