BDBM50303287 1-(4-(4-(8-oxa-3-azabicyclo[3.2.1]octan-3-yl)-1-ethyl-1H-pyrazolo[3,4-d]pyrimidin-6-yl)phenyl)-3-(6-morpholinopyridin-3-yl)urea::CHEMBL576304

SMILES CCn1ncc2c(nc(nc12)-c1ccc(NC(=O)Nc2ccc(nc2)N2CCOCC2)cc1)N1CC2CCC(C1)O2

InChI Key InChIKey=RCWCYHYCUNPFSO-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50303287   

TargetSerine/threonine-protein kinase mTOR(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50303287(1-(4-(4-(8-oxa-3-azabicyclo[3.2.1]octan-3-yl)-1-et...)
Affinity DataIC50: 0.300nMAssay Description:Inhibition of human FLAG-tagged mTOR expressed in HEK293 cells after 2 hrs by DELFIAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2010
Entry Details Article
PubMed
LigandPNGBDBM50303287(1-(4-(4-(8-oxa-3-azabicyclo[3.2.1]octan-3-yl)-1-et...)
Affinity DataIC50: 2.15E+3nMAssay Description:Binding affinity to PI3Kalpha by fluorescence polarization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2010
Entry Details Article
PubMed