BDBM50303821 (R)-1-((5aR,6S)-1-(4-Fluorophenyl)-5a-methyl-5,5a,6,7,8,9-hexahydroimidazo[1,5-b]isoquinolin-6-yl)-1-(tetrahydro-2H-pyran-4-yl)-ethanol::CHEMBL572355

SMILES C[C@@](O)(C1CCOCC1)[C@H]1CCCC2=Cc3c(ncn3C[C@]12C)-c1ccc(F)cc1

InChI Key InChIKey=XIEBKQNZRFBICJ-UHFFFAOYSA-N

Data  1 KI  1 IC50  3 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50303821   

TargetGlucocorticoid receptor(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50303821((R)-1-((5aR,6S)-1-(4-Fluorophenyl)-5a-methyl-5,5a,...)
Affinity DataKi:  2nMAssay Description:Displacement of GS-red from human glucocorticoid receptor by fluorescent polarization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/27/2012
Entry Details Article
PubMed
TargetGlucocorticoid receptor(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50303821((R)-1-((5aR,6S)-1-(4-Fluorophenyl)-5a-methyl-5,5a,...)
Affinity DataEC50:  48nMAssay Description:Transrepression activity at glucocorticoid receptor expressed in human A549 cells assessed as inhibition of IL-1-beta-induced NF-kappaB dependent E-s...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/27/2012
Entry Details Article
PubMed
TargetGlucocorticoid receptor(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50303821((R)-1-((5aR,6S)-1-(4-Fluorophenyl)-5a-methyl-5,5a,...)
Affinity DataEC50:  57nMAssay Description:Transrepression activity at glucocorticoid receptor expressed in human A549 cells assessed as inhibition of PMA-induced AP1 activity after 6 hrs by l...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/27/2012
Entry Details Article
PubMed
TargetGlucocorticoid receptor(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50303821((R)-1-((5aR,6S)-1-(4-Fluorophenyl)-5a-methyl-5,5a,...)
Affinity DataEC50: >1.00E+3nMAssay Description:Transactivation of GAL-4 tagged glucocorticoid receptor ligand binding domain expressed in human HeLa cells assessed as NP1 activation by luciferase ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/27/2012
Entry Details Article
PubMed
TargetAndrogen receptor(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50303821((R)-1-((5aR,6S)-1-(4-Fluorophenyl)-5a-methyl-5,5a,...)
Affinity DataIC50: 4.00E+3nMAssay Description:Binding affinity to androgen receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/27/2012
Entry Details Article
PubMed