BDBM50303832 (4-fluorophenyl)-((5aR,6S)-1-(4-fluorophenyl)-5a-methyl-5,5a,6,7,8,9-hexahydroimidazo[1,5-b]isoquinolin-6-yl)methanol::CHEMBL583858

SMILES C[C@]12Cn3cnc(c3C=C1CCC[C@@H]2[C@H](O)c1ccc(F)cc1)-c1ccc(F)cc1

InChI Key InChIKey=YXQPDNYJXVGIES-UHFFFAOYSA-N

Data  3 KI  4 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 50303832   

TargetGlucocorticoid receptor(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50303832((4-fluorophenyl)-((5aR,6S)-1-(4-fluorophenyl)-5a-m...)
Affinity DataKi:  25nMAssay Description:Displacement of GS-red from human glucocorticoid receptor by fluorescent polarization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/27/2012
Entry Details Article
PubMed
TargetGlucocorticoid receptor(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50303832((4-fluorophenyl)-((5aR,6S)-1-(4-fluorophenyl)-5a-m...)
Affinity DataKi:  25nMAssay Description:Displacement of GS-red from human glucocorticoid receptor by fluorescent polarization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/27/2012
Entry Details Article
PubMed
TargetGlucocorticoid receptor(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50303832((4-fluorophenyl)-((5aR,6S)-1-(4-fluorophenyl)-5a-m...)
Affinity DataEC50:  243nMAssay Description:Transrepression activity at glucocorticoid receptor expressed in human A549 cells assessed as inhibition of IL-1-beta-induced NF-kappaB dependent E-s...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/27/2012
Entry Details Article
PubMed
TargetGlucocorticoid receptor(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50303832((4-fluorophenyl)-((5aR,6S)-1-(4-fluorophenyl)-5a-m...)
Affinity DataEC50:  272nMAssay Description:Transrepression activity at glucocorticoid receptor expressed in human A549 cells assessed as inhibition of PMA-induced AP1 activity after 6 hrs by l...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/27/2012
Entry Details Article
PubMed
TargetProgesterone receptor(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50303832((4-fluorophenyl)-((5aR,6S)-1-(4-fluorophenyl)-5a-m...)
Affinity DataKi:  451nMAssay Description:Binding affinity to progesterone receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/27/2012
Entry Details Article
PubMed
TargetGlucocorticoid receptor(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50303832((4-fluorophenyl)-((5aR,6S)-1-(4-fluorophenyl)-5a-m...)
Affinity DataEC50: >5.00E+3nMAssay Description:Transrepression activity at glucocorticoid receptor expressed in human A549 cells assessed as inhibition of PMA-induced AP1 activity after 6 hrs by l...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/27/2012
Entry Details Article
PubMed
TargetGlucocorticoid receptor(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50303832((4-fluorophenyl)-((5aR,6S)-1-(4-fluorophenyl)-5a-m...)
Affinity DataEC50: >5.00E+3nMAssay Description:Transrepression activity at glucocorticoid receptor expressed in human A549 cells assessed as inhibition of IL-1-beta-induced NF-kappaB dependent E-s...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/27/2012
Entry Details Article
PubMed