BDBM50304213 CHEMBL593275::N-[4-(6''-Fluorobenzo[d]thiazol-2''-yl)phenyl]-6'-methoxy-7'-[3-(4-methylpiperazin-1-yl)propoxy]quinazolin-4'-amine

SMILES COc1cc2c(Nc3ccc(cc3)-c3nc4ccc(Cl)cc4s3)ncnc2cc1OCCCN1CCN(C)CC1

InChI Key InChIKey=WMBJPWPAQLGSFL-UHFFFAOYSA-N

Data  8 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 50304213   

TargetAurora kinase A(Human)
4Sc

Curated by ChEMBL
LigandPNGBDBM50304213(N-[4-(6''-Fluorobenzo[d]thiazol-2''-yl)phenyl]-6'-...)
Affinity DataIC50: 54nMAssay Description:Inhibition of Aurora-A by microplate scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2010
Entry Details Article
PubMed
TargetAurora kinase B(Human)
4Sc

Curated by ChEMBL
LigandPNGBDBM50304213(N-[4-(6''-Fluorobenzo[d]thiazol-2''-yl)phenyl]-6'-...)
Affinity DataIC50: 64nMAssay Description:Inhibition of Aurora-B by microplate scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2010
Entry Details Article
PubMed
TargetEpidermal growth factor receptor(Human)
4Sc

Curated by ChEMBL
LigandPNGBDBM50304213(N-[4-(6''-Fluorobenzo[d]thiazol-2''-yl)phenyl]-6'-...)
Affinity DataIC50: 260nMAssay Description:Inhibition of wild type EGF-R by microplate scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2010
Entry Details Article
PubMed
TargetAngiopoietin-1 receptor(Human)
4Sc

Curated by ChEMBL
LigandPNGBDBM50304213(N-[4-(6''-Fluorobenzo[d]thiazol-2''-yl)phenyl]-6'-...)
Affinity DataIC50: 410nMAssay Description:Inhibition of TIE2 by microplate scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2010
Entry Details Article
PubMed
LigandPNGBDBM50304213(N-[4-(6''-Fluorobenzo[d]thiazol-2''-yl)phenyl]-6'-...)
Affinity DataIC50: 2.30E+3nMAssay Description:Inhibition of ERBB2 by microplate scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2010
Entry Details Article
PubMed
LigandPNGBDBM50304213(N-[4-(6''-Fluorobenzo[d]thiazol-2''-yl)phenyl]-6'-...)
Affinity DataIC50: 2.50E+3nMAssay Description:Inhibition of VEGFR2 by microplate scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2010
Entry Details Article
PubMed
LigandPNGBDBM50304213(N-[4-(6''-Fluorobenzo[d]thiazol-2''-yl)phenyl]-6'-...)
Affinity DataIC50: 8.00E+3nMAssay Description:Inhibition of PDGFRbeta by microplate scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2010
Entry Details Article
PubMed
LigandPNGBDBM50304213(N-[4-(6''-Fluorobenzo[d]thiazol-2''-yl)phenyl]-6'-...)
Affinity DataIC50: 9.30E+3nMAssay Description:Inhibition of VEGFR3 by microplate scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2010
Entry Details Article
PubMed