BDBM50305110 (+)-3-(4-((cyclopropylmethyl)(1-oxo-1,2,3,7,8,9-hexahydropyrano[3,2-e]isoindol-8-yl)amino)butyl)-1H-indole-5-carbonitrile::(+/-)-3-(4-((cyclopropylmethyl)(1-oxo-1,2,3,7,8,9-hexahydropyrano[3,2-e]isoindol-8-yl)amino)butyl)-1H-indole-5-carbonitrile::(-)-3-(4-((cyclopropylmethyl)(1-oxo-1,2,3,7,8,9-hexahydropyrano[3,2-e]isoindol-8-yl)amino)butyl)-1H-indole-5-carbonitrile::CHEMBL596297

SMILES O=C1NCc2ccc3OCC(Cc3c12)N(CCCCc1c[nH]c2ccc(cc12)C#N)CC1CC1

InChI Key InChIKey=MPWYHMZQNZPQHG-UHFFFAOYSA-N

Data  6 KI  2 IC50  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 9 hits for monomerid = 50305110   

Target5-hydroxytryptamine receptor 1A(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50305110((-)-3-(4-((cyclopropylmethyl)(1-oxo-1,2,3,7,8,9-he...)
Affinity DataIC50: 63nMAssay Description:Agonist activity at human 5HT1A receptor expressed in CHO cells assessed as inhibition of forskolin-induced adenylate cyclase activityMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2010
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 1A(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50305110((-)-3-(4-((cyclopropylmethyl)(1-oxo-1,2,3,7,8,9-he...)
Affinity DataIC50: 63nMAssay Description:Agonist activity at human 5HT1A receptor expressed in CHO cells assessed as inhibition of forskolin-induced adenylate cyclase activityMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2010
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 1A(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50305110((-)-3-(4-((cyclopropylmethyl)(1-oxo-1,2,3,7,8,9-he...)
Affinity DataEC50:  19nMAssay Description:Agonist activity at human 5HT1A receptor expressed in CHO cells assessed as inhibition of forskolin-induced adenylate cyclase activityMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2010
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 1A(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50305110((-)-3-(4-((cyclopropylmethyl)(1-oxo-1,2,3,7,8,9-he...)
Affinity DataKi:  4nMAssay Description:Displacement of [3H]OH-DPAP from human 5HT1A receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2010
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 1A(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50305110((-)-3-(4-((cyclopropylmethyl)(1-oxo-1,2,3,7,8,9-he...)
Affinity DataKi:  4nMAssay Description:Displacement of [3H]OH-DPAP from human 5HT1A receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2010
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 1A(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50305110((-)-3-(4-((cyclopropylmethyl)(1-oxo-1,2,3,7,8,9-he...)
Affinity DataKi:  10nMAssay Description:Displacement of [3H]OH-DPAP from human 5HT1A receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2010
Entry Details Article
PubMed
TargetSodium-dependent serotonin transporter(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50305110((-)-3-(4-((cyclopropylmethyl)(1-oxo-1,2,3,7,8,9-he...)
Affinity DataKi:  17nMAssay Description:Displacement of labeled paroxetine from 5-HT transporterMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2010
Entry Details Article
PubMed
TargetSodium-dependent serotonin transporter(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50305110((-)-3-(4-((cyclopropylmethyl)(1-oxo-1,2,3,7,8,9-he...)
Affinity DataKi:  25nMAssay Description:Displacement of labeled paroxetine from 5-HT transporterMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2010
Entry Details Article
PubMed
TargetSodium-dependent serotonin transporter(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50305110((-)-3-(4-((cyclopropylmethyl)(1-oxo-1,2,3,7,8,9-he...)
Affinity DataKi:  25nMAssay Description:Displacement of labeled paroxetine from 5-HT transporterMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2010
Entry Details Article
PubMed