BDBM50306254 1-(2-(4-methylthiazol-2-yl)acetyl)-2,3,9,9a-tetrahydro-1H-benzo[de][1,7]naphthyridin-7(8H)-one::CHEMBL595019

SMILES Cc1csc(CC(=O)N2CCc3cccc4C(=O)NCC2c34)n1

InChI Key InChIKey=BIEHYKHVCMIZHI-UHFFFAOYSA-N

Data  1 IC50  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50306254   

TargetPoly [ADP-ribose] polymerase 1(Human)
Irbm-Merck Research Laboratories Rome

Curated by ChEMBL
LigandPNGBDBM50306254(1-(2-(4-methylthiazol-2-yl)acetyl)-2,3,9,9a-tetrah...)
Affinity DataIC50: 6nMAssay Description:Inhibition of human PARP1 by scintillation proximity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/1/2010
Entry Details Article
PubMed
TargetPoly [ADP-ribose] polymerase 1(Human)
Irbm-Merck Research Laboratories Rome

Curated by ChEMBL
LigandPNGBDBM50306254(1-(2-(4-methylthiazol-2-yl)acetyl)-2,3,9,9a-tetrah...)
Affinity DataEC50:  2.90E+3nMAssay Description:Inhibition of PARP1 in human HeLa cells assessed as inhibition of hydrogen peroxide-induced poly(ADP-ribosyl)ationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/1/2010
Entry Details Article
PubMed