BDBM50306384 5-(4-(3-chloro-5-(trifluoromethyl)pyridin-2-yloxy)-2-methylbenzyl)thiazolidine-2,4-dione::CHEMBL604126

SMILES Cc1cc(Oc2ncc(cc2Cl)C(F)(F)F)ccc1Cc1sc(=O)[nH]c1O

InChI Key InChIKey=YJDOOYZCAIEGLO-UHFFFAOYSA-N

Data  1 KI  3 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50306384   

TargetFree fatty acid receptor 1(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50306384(5-(4-(3-chloro-5-(trifluoromethyl)pyridin-2-yloxy)...)
Affinity DataEC50:  10nMAssay Description:Agonist activity at human GPR40 by FLIPR assay in presence of 1% BSAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/1/2010
Entry Details Article
PubMed
TargetFree fatty acid receptor 1(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50306384(5-(4-(3-chloro-5-(trifluoromethyl)pyridin-2-yloxy)...)
Affinity DataEC50:  55nMAssay Description:Agonist activity at human C-terminal eYFP-tagged FFA1 receptor expressed in HEK-293 cells assessed as beta-arrestin2 recruitment incubated for 5 mins...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/23/2017
Entry Details Article
PubMed
TargetFree fatty acid receptor 1(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50306384(5-(4-(3-chloro-5-(trifluoromethyl)pyridin-2-yloxy)...)
Affinity DataKi:  69nMAssay Description:Displacement of 3-(2-Fluoro-4-((2'-methyl-4'-(2-(2-((7-nitrobenzo[c][1,2,5]-oxadiazol-4-yl)amino)ethoxy)ethoxy)-[1,1'-biphenyl]-3-yl)-methoxy)phenyl)...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/23/2017
Entry Details Article
PubMed
TargetFree fatty acid receptor 1(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50306384(5-(4-(3-chloro-5-(trifluoromethyl)pyridin-2-yloxy)...)
Affinity DataEC50:  87.1nMAssay Description:Agonist activity at human FFA1 receptor expressed in human 1321N1 cells assessed as calcium mobilization by fluorescence spectrophotometryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/22/2013
Entry Details Article
PubMed