BDBM50307934 CHEMBL597200::N-(4-(3-Bromoanilino)quinazolin-6-yl)-2-(4-fluorophenoxy)-acetamide

SMILES Fc1ccc(OCC(=O)Nc2ccc3ncnc(Nc4cccc(Br)c4)c3c2)cc1

InChI Key InChIKey=KHWGVPOXFZQODO-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50307934   

TargetEpidermal growth factor receptor(Human)
University of Parma

Curated by ChEMBL
LigandPNGBDBM50307934(N-(4-(3-Bromoanilino)quinazolin-6-yl)-2-(4-fluorop...)
Affinity DataIC50: 8.43nMAssay Description:Inhibition of human recombinant EGFR expressed in insect cells by time-resolved fluorimetryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/1/2010
Entry Details Article
PubMed
TargetEpidermal growth factor receptor(Human)
University of Parma

Curated by ChEMBL
LigandPNGBDBM50307934(N-(4-(3-Bromoanilino)quinazolin-6-yl)-2-(4-fluorop...)
Affinity DataIC50: 31nMAssay Description:Inhibition of EGFR autophosphorylation in human A431 cells after 1 hr by Western blotMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/1/2010
Entry Details Article
PubMed
TargetEpidermal growth factor receptor(Human)
University of Parma

Curated by ChEMBL
LigandPNGBDBM50307934(N-(4-(3-Bromoanilino)quinazolin-6-yl)-2-(4-fluorop...)
Affinity DataIC50: 291nMAssay Description:Inhibition of EGFR autophosphorylation in human A431 cells after 8 hrs by Western blotMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/1/2010
Entry Details Article
PubMed