BDBM50309832 2H-chromeno[2,3-d]pyrimidine-2,4(3H)-dione::CHEMBL611665::US10226464, Compound 9

SMILES O=c1nc2oc3ccccc3cc2c(=O)[nH]1

InChI Key InChIKey=BFMCRAXOACCPEL-UHFFFAOYSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50309832   

TargetNAD-dependent protein deacetylase sirtuin-1(Human)
Institute of Psychiatry and Neuroscience of Paris

Curated by ChEMBL
LigandPNGBDBM50309832(2H-chromeno[2,3-d]pyrimidine-2,4(3H)-dione | CHEMB...)
Affinity DataIC50: 5.30E+3nMAssay Description:Inhibition of human recombinant SIRT1 by Flour de Lys assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/2/2010
Entry Details Article
PubMed
TargetNAD-dependent protein deacetylase sirtuin-2(Human)
Institute of Psychiatry and Neuroscience of Paris

Curated by ChEMBL
LigandPNGBDBM50309832(2H-chromeno[2,3-d]pyrimidine-2,4(3H)-dione | CHEMB...)
Affinity DataIC50: 2.44E+5nMAssay Description:Inhibition of human recombinant SIRT2 by Flour de Lys assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/2/2010
Entry Details Article
PubMed
TargetNuclear factor NF-kappa-B p105 subunit(Human)
Immunetarget

US Patent
LigandPNGBDBM50309832(2H-chromeno[2,3-d]pyrimidine-2,4(3H)-dione | CHEMB...)
Affinity DataIC50: 5.00E+3nMAssay Description:DNA binding reaction (20 μL) was carried out in 1×DNA Binding Buffer (10 mM Tris, 40 mM NaCl, 1 mM EDTA, 4% glycerol) with 10 nM c-Rel protein a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/27/2019
Entry Details
Go to US Patent

TargetNuclear factor NF-kappa-B p105 subunit(Human)
Immunetarget

US Patent
LigandPNGBDBM50309832(2H-chromeno[2,3-d]pyrimidine-2,4(3H)-dione | CHEMB...)
Affinity DataIC50: 2.00E+4nMAssay Description:NFκB/Jurkat/GFP transcriptional reporter cell line was obtained from SBI System Biosciences. NF-κB/Jurkat/GFP Reporter cells (5×105 cells) ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/27/2019
Entry Details
Go to US Patent

TargetNAD-dependent protein deacetylase sirtuin-1(Human)
Institute of Psychiatry and Neuroscience of Paris

Curated by ChEMBL
LigandPNGBDBM50309832(2H-chromeno[2,3-d]pyrimidine-2,4(3H)-dione | CHEMB...)
Affinity DataIC50: 5.30E+3nMAssay Description:Inhibition of recombinant human SIRT1 expressed in Escherichia coli using Fluor de Lys-SIRT1/2 substrate in presence of NAD+ by fluorescence micropla...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetNAD-dependent protein deacetylase sirtuin-2(Human)
Institute of Psychiatry and Neuroscience of Paris

Curated by ChEMBL
LigandPNGBDBM50309832(2H-chromeno[2,3-d]pyrimidine-2,4(3H)-dione | CHEMB...)
Affinity DataIC50: 2.44E+5nMAssay Description:Inhibition of recombinant human SIRT2 expressed in Escherichia coli using Fluor de Lys-SIRT1/2 substrate in presence of NAD+ by fluorescence micropla...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed