BDBM50310376 (S)-5-[4-(2-Diethylamino-ethoxy)-phenyl]-8-fluoro-11,12-dihydro-5H-6,13-dioxa-benzo[3,4]cyclohepta[1,2-a]naphthalen-2-ol::CHEMBL1084120

SMILES CCN(CC)CCOc1ccc(cc1)[C@@H]1Oc2cc(F)ccc2C2=C1c1ccc(O)cc1OCC2

InChI Key InChIKey=FEVNXNWGPTZNEC-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50310376   

TargetEstrogen receptor beta(Human)
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50310376((S)-5-[4-(2-Diethylamino-ethoxy)-phenyl]-8-fluoro-...)
Affinity DataIC50: 11nMAssay Description:Inhibition of fluormone ES2 binding to estrogen receptor beta after 1 hr by fluorescence polarization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/16/2010
Entry Details Article
PubMed
TargetEstrogen receptor(Human)
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50310376((S)-5-[4-(2-Diethylamino-ethoxy)-phenyl]-8-fluoro-...)
Affinity DataIC50: 122nMAssay Description:Antagonist activity at estrogen receptor in human Ishikawa cells assessed as 17-beta-estradiol-induced alkaline phosphatase activity after 3 days by ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/16/2010
Entry Details Article
PubMed
TargetEstrogen receptor(Human)
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50310376((S)-5-[4-(2-Diethylamino-ethoxy)-phenyl]-8-fluoro-...)
Affinity DataIC50: 1.20E+3nMAssay Description:Antagonist activity at estrogen receptor in human MCF7 cells assessed as 17-beta-estradiol-induced cell proliferation after 24 hrs by [14C]thymidine ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/16/2010
Entry Details Article
PubMed
TargetEstrogen receptor(Human)
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50310376((S)-5-[4-(2-Diethylamino-ethoxy)-phenyl]-8-fluoro-...)
Affinity DataIC50: 7nMAssay Description:Displacement of radiolabeled estrogen from estrogen receptor alpha by scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/16/2010
Entry Details Article
PubMed