BDBM50310383 5S-(-)-[4-(2-diisopropylaminoethoxy)phenyl]-11,12-dihydro-5H-6,13-dioxabenzo[3,4]cyclohepta-[1,2-a]naphthalene-2,8-diol::CHEMBL1085899

SMILES CC(C)N(CCOc1ccc(cc1)[C@@H]1Oc2cc(O)ccc2C2=C1c1ccc(O)cc1OCC2)C(C)C

InChI Key InChIKey=IBWJCHNKSFDWMJ-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50310383   

TargetEstrogen receptor beta(Human)
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50310383(5S-(-)-[4-(2-diisopropylaminoethoxy)phenyl]-11,12-...)
Affinity DataIC50: 18.5nMAssay Description:Inhibition of fluormone ES2 binding to estrogen receptor beta after 1 hr by fluorescence polarization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/16/2010
Entry Details Article
PubMed
TargetEstrogen receptor(Human)
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50310383(5S-(-)-[4-(2-diisopropylaminoethoxy)phenyl]-11,12-...)
Affinity DataIC50: 5.60nMAssay Description:Displacement of radiolabeled estrogen from estrogen receptor alpha by scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/16/2010
Entry Details Article
PubMed
TargetEstrogen receptor(Human)
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50310383(5S-(-)-[4-(2-diisopropylaminoethoxy)phenyl]-11,12-...)
Affinity DataIC50: 35nMAssay Description:Antagonist activity at estrogen receptor in human Ishikawa cells assessed as 17-beta-estradiol-induced alkaline phosphatase activity after 3 days by ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/16/2010
Entry Details Article
PubMed
TargetEstrogen receptor(Human)
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50310383(5S-(-)-[4-(2-diisopropylaminoethoxy)phenyl]-11,12-...)
Affinity DataIC50: 424nMAssay Description:Antagonist activity at estrogen receptor in human MCF7 cells assessed as 17-beta-estradiol-induced cell proliferation after 24 hrs by [14C]thymidine ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/16/2010
Entry Details Article
PubMed