BDBM50310425 5S-(-)-[4-(2-azepan-1-ylethoxy)phenyl]-11,12-dihydro-5H-6,13-dioxabenzo[3,4]cyclohepta[1,2-a]naphthalen-8-ol::CHEMBL1087418

SMILES Oc1ccc2C3=C([C@@H](Oc2c1)c1ccc(OCCN2CCCCCC2)cc1)c1ccccc1OCC3

InChI Key InChIKey=YVAJBGGOMIUCAI-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50310425   

TargetEstrogen receptor(Human)
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50310425(5S-(-)-[4-(2-azepan-1-ylethoxy)phenyl]-11,12-dihyd...)
Affinity DataIC50: 1.84E+3nMAssay Description:Antagonist activity at estrogen receptor in human MCF7 cells assessed as 17-beta-estradiol-induced cell proliferation after 24 hrs by [14C]thymidine ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/16/2010
Entry Details Article
PubMed
TargetEstrogen receptor beta(Human)
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50310425(5S-(-)-[4-(2-azepan-1-ylethoxy)phenyl]-11,12-dihyd...)
Affinity DataIC50: 41nMAssay Description:Inhibition of fluormone ES2 binding to estrogen receptor beta after 1 hr by fluorescence polarization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/16/2010
Entry Details Article
PubMed
TargetEstrogen receptor(Human)
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50310425(5S-(-)-[4-(2-azepan-1-ylethoxy)phenyl]-11,12-dihyd...)
Affinity DataIC50: 4nMAssay Description:Displacement of radiolabeled estrogen from estrogen receptor alpha by scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/16/2010
Entry Details Article
PubMed
TargetEstrogen receptor(Human)
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50310425(5S-(-)-[4-(2-azepan-1-ylethoxy)phenyl]-11,12-dihyd...)
Affinity DataIC50: 144nMAssay Description:Antagonist activity at estrogen receptor in human Ishikawa cells assessed as 17-beta-estradiol-induced alkaline phosphatase activity after 3 days by ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/16/2010
Entry Details Article
PubMed