BDBM50312273 (1R,5S/1S,5R)-1-[2-Fluoro-4-(trifluoromethyl)phenyl]-3-(3-{[4-methyl-5-(4-methyl-1,3-oxazol-5-yl)-4H-1,2,4-triazol-3-yl]thio}-propyl)-3-azabicyclo[3.1.0]hexane::5-(5-(3-(1-(2-fluoro-4-(trifluoromethyl)phenyl)-3-azabicyclo[3.1.0]hexan-3-yl)propylthio)-4-methyl-4H-1,2,4-triazol-3-yl)-4-methyloxazole::CHEMBL1081023

SMILES Cc1ncoc1-c1nnc(SCCCN2CC3CC3(C2)c2ccc(cc2F)C(F)(F)F)n1C

InChI Key InChIKey=ZKRWPAYTJMRKLJ-UHFFFAOYSA-N

Data  1 KI  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50312273   

TargetPotassium voltage-gated channel subfamily H member 2(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50312273((1R,5S/1S,5R)-1-[2-Fluoro-4-(trifluoromethyl)pheny...)
Affinity DataIC50: 460nMAssay Description:Inhibition of human ERG by patch clamp electrophysiology assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/17/2010
Entry Details Article
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50312273((1R,5S/1S,5R)-1-[2-Fluoro-4-(trifluoromethyl)pheny...)
Affinity DataIC50: 1.00E+3nMAssay Description:Displacement of [3H]dofetidile from human ERG by scintillation proximity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/17/2010
Entry Details Article
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50312273((1R,5S/1S,5R)-1-[2-Fluoro-4-(trifluoromethyl)pheny...)
Affinity DataIC50: 999nMAssay Description:Displacement of [3H]dofetidile from human ERG by scintillation proximity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/17/2010
Entry Details Article
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50312273((1R,5S/1S,5R)-1-[2-Fluoro-4-(trifluoromethyl)pheny...)
Affinity DataIC50: 794nMAssay Description:Displacement of [3H]dofetidile from human ERG by scintillation proximity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/17/2010
Entry Details Article
PubMed
TargetD(3) dopamine receptor(Rat)
University of Michigan

Curated by ChEMBL
LigandPNGBDBM50312273((1R,5S/1S,5R)-1-[2-Fluoro-4-(trifluoromethyl)pheny...)
Affinity DataKi:  46nMAssay Description:Displacement of [3H]R-(+)-7-OHDPAT from dopamine D3 receptor in Sprague-Dawley rat ventral striatum after 90 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/10/2015
Entry Details Article
PubMed