BDBM50312526 CHEMBL1076754::N-Butyl-L-ido-1-deoxynojirimycin

SMILES CCCCN1C[C@H](O)[C@@H](O)[C@H](O)[C@@H]1CO

InChI Key InChIKey=UQRORFVVSGFNRO-UHFFFAOYSA-N

Data  15 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 15 hits for monomerid = 50312526   

TargetSucrase-isomaltase, intestinal(Human)
Leiden University

Curated by ChEMBL
LigandPNGBDBM50312526(N-Butyl-L-ido-1-deoxynojirimycin | CHEMBL1076754)
Affinity DataIC50: 1.00E+6nMAssay Description:Inhibition of sucrase by HPLCMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/17/2010
Entry Details Article
PubMed
TargetCeramide glucosyltransferase(Human)
Leiden University

Curated by ChEMBL
LigandPNGBDBM50312526(N-Butyl-L-ido-1-deoxynojirimycin | CHEMBL1076754)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of glucosylceramide synthase (unknown origin) assessed as catabolism of NBD-glucosylceramideMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/9/2016
Entry Details Article
PubMed
TargetNon-lysosomal glucosylceramidase(Human)
Leiden University

Curated by ChEMBL
LigandPNGBDBM50312526(N-Butyl-L-ido-1-deoxynojirimycin | CHEMBL1076754)
Affinity DataIC50: 250nMAssay Description:Inhibition of GBA2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/9/2016
Entry Details Article
PubMed
TargetCeramide glucosyltransferase(Human)
Leiden University

Curated by ChEMBL
LigandPNGBDBM50312526(N-Butyl-L-ido-1-deoxynojirimycin | CHEMBL1076754)
Affinity DataIC50: 1.20E+4nMAssay Description:Inhibition of GCS by cell-based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/17/2010
Entry Details Article
PubMed
TargetLactase/phlorizin hydrolase(Human)
Leiden University

Curated by ChEMBL
LigandPNGBDBM50312526(N-Butyl-L-ido-1-deoxynojirimycin | CHEMBL1076754)
Affinity DataIC50: 1.00E+6nMAssay Description:Inhibition of lactase by HPLCMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/17/2010
Entry Details Article
PubMed
TargetNon-lysosomal glucosylceramidase(Human)
Leiden University

Curated by ChEMBL
LigandPNGBDBM50312526(N-Butyl-L-ido-1-deoxynojirimycin | CHEMBL1076754)
Affinity DataIC50: 250nMAssay Description:Inhibition of GBA2 by HPLCMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/17/2010
Entry Details Article
PubMed
TargetLysosomal alpha-glucosidase(Human)
Leiden University

Curated by ChEMBL
LigandPNGBDBM50312526(N-Butyl-L-ido-1-deoxynojirimycin | CHEMBL1076754)
Affinity DataIC50: 1.00E+6nMAssay Description:Inhibition of lysosomal alpha-glucosidase by HPLCMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/17/2010
Entry Details Article
PubMed
TargetGlycogen debranching enzyme(Human)
Leiden University

Curated by ChEMBL
LigandPNGBDBM50312526(N-Butyl-L-ido-1-deoxynojirimycin | CHEMBL1076754)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of glycogen glycogen de-branching enzyme by HPLCMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/17/2010
Entry Details Article
PubMed
TargetMaltase-glucoamylase(Human)
Leiden University

Curated by ChEMBL
LigandPNGBDBM50312526(N-Butyl-L-ido-1-deoxynojirimycin | CHEMBL1076754)
Affinity DataIC50: 1.00E+6nMAssay Description:Inhibition of maltase by HPLCMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/17/2010
Entry Details Article
PubMed
TargetLysosomal acid glucosylceramidase(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50312526(N-Butyl-L-ido-1-deoxynojirimycin | CHEMBL1076754)
Affinity DataIC50: 1.00E+6nMAssay Description:Inhibition of recombinant GBA1 preincubated with compound for 30 mins using 4-methylumbelliferyl-B-glucoside substrate by fluorimetric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2011
Entry Details Article
PubMed
TargetCeramide glucosyltransferase(Mouse)
TBA

Curated by ChEMBL
LigandPNGBDBM50312526(N-Butyl-L-ido-1-deoxynojirimycin | CHEMBL1076754)
Affinity DataIC50: 2.00E+4nMAssay Description:Inhibition of glucosylceramide synthase in mouse RAW cells preincubated with compound for 15 mins by in-situ enzyme inhibition assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2011
Entry Details Article
PubMed
TargetLysosomal alpha-glucosidase(Mouse)
TBA

Curated by ChEMBL
LigandPNGBDBM50312526(N-Butyl-L-ido-1-deoxynojirimycin | CHEMBL1076754)
Affinity DataIC50: 1.00E+6nMAssay Description:Inhibition of maltase in mouse intestinal input by glucose release assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2011
Entry Details Article
PubMed
TargetBeta-galactosidase(Mouse)
TBA

Curated by ChEMBL
LigandPNGBDBM50312526(N-Butyl-L-ido-1-deoxynojirimycin | CHEMBL1076754)
Affinity DataIC50: 1.00E+6nMAssay Description:Inhibition of lactase in mouse intestinal input by glucose release assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2011
Entry Details Article
PubMed
TargetSucrase-isomaltase(Mouse)
TBA

Curated by ChEMBL
LigandPNGBDBM50312526(N-Butyl-L-ido-1-deoxynojirimycin | CHEMBL1076754)
Affinity DataIC50: 1.00E+6nMAssay Description:Inhibition of sucrase in mouse intestinal input by glucose release assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2011
Entry Details Article
PubMed
TargetNon-lysosomal glucosylceramidase(Human)
Leiden University

Curated by ChEMBL
LigandPNGBDBM50312526(N-Butyl-L-ido-1-deoxynojirimycin | CHEMBL1076754)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of recombinant GBA2 preincubated with compound for 30 mins using 4-methylumbelliferyl-B-glucoside substrate by fluorimetric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2011
Entry Details Article
PubMed