BDBM50313150 8-amino-2,7-diisobutyl-4-isopentyl-4,5-dihydro-1H-benzo[e][1,4]diazepin-3(2H)-one::CHEMBL1087253

SMILES CC(C)CCN1Cc2cc(CC(C)C)c(N)cc2N[C@@H](CC(C)C)C1=O

InChI Key InChIKey=DAWHMMINFGNTOI-UHFFFAOYSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50313150   

TargetVitamin D3 receptor(Human)
The University of Tokyo

Curated by ChEMBL
LigandPNGBDBM50313150(8-amino-2,7-diisobutyl-4-isopentyl-4,5-dihydro-1H-...)
Affinity DataIC50: 3.00E+4nMAssay Description:Displacement of 1,25-dihydroxyvitamin D3 from GST-tagged VDR ligand binding domain assessed as inhibition of interaction with coactivator proteins by...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/17/2010
Entry Details Article
PubMed
TargetVitamin D3 receptor(Human)
The University of Tokyo

Curated by ChEMBL
LigandPNGBDBM50313150(8-amino-2,7-diisobutyl-4-isopentyl-4,5-dihydro-1H-...)
Affinity DataIC50: 3.00E+4nMAssay Description:Antagonist activity at human recombinant VDR LBD expressed in HEK293 cells assessed as inhibition of 3 nM 1,25-(OH)2D3-induced transcriptional activa...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/17/2010
Entry Details Article
PubMed
TargetEstrogen receptor beta(Human)
The University of Tokyo

Curated by ChEMBL
LigandPNGBDBM50313150(8-amino-2,7-diisobutyl-4-isopentyl-4,5-dihydro-1H-...)
Affinity DataIC50: 3.00E+4nMAssay Description:Antagonist activity at human recombinant ERbeta LBD expressed in HEK293 cells assessed as inhibition of 0.3 nM estradiol-induced transcriptional acti...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/17/2010
Entry Details Article
PubMed
TargetVitamin D3 receptor(Human)
The University of Tokyo

Curated by ChEMBL
LigandPNGBDBM50313150(8-amino-2,7-diisobutyl-4-isopentyl-4,5-dihydro-1H-...)
Affinity DataIC50: 3.00E+4nMAssay Description:Antagonist activity at human recombinant VDR LBD expressed in HEK293 cells assessed as inhibition of 300 nM 1,25-(OH)2D3-induced transcriptional acti...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/17/2010
Entry Details Article
PubMed
TargetEstrogen receptor(Human)
The University of Tokyo

Curated by ChEMBL
LigandPNGBDBM50313150(8-amino-2,7-diisobutyl-4-isopentyl-4,5-dihydro-1H-...)
Affinity DataIC50: 3.00E+4nMAssay Description:Antagonist activity at human recombinant ERalpha LBD expressed in HEK293 cells assessed as inhibition of 0.3 nM estradiol-induced transcriptional act...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/17/2010
Entry Details Article
PubMed