BDBM50313628 (6R,7S,7aS)-6-((R)-1-(3,5-bis(trifluoromethyl)phenyl)ethoxy)-7-(4-fluorophenyl)-2-hydroxy-2-methyltetrahydro-1H-pyrrolizin-3(2H)-one::CHEMBL1091469

SMILES C[C@@H](O[C@H]1CN2[C@@H](CC(C)(O)C2=O)[C@@H]1c1ccc(F)cc1)c1cc(cc(c1)C(F)(F)F)C(F)(F)F

InChI Key InChIKey=GDTPPOVBSGSQJY-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50313628   

TargetSubstance-P receptor(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50313628((6R,7S,7aS)-6-((R)-1-(3,5-bis(trifluoromethyl)phen...)
Affinity DataIC50: 0.0900nMAssay Description:Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2010
Entry Details Article
PubMed
TargetSubstance-P receptor(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50313628((6R,7S,7aS)-6-((R)-1-(3,5-bis(trifluoromethyl)phen...)
Affinity DataIC50: 0.0900nMAssay Description:Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2010
Entry Details Article
PubMed
TargetSubstance-P receptor(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50313628((6R,7S,7aS)-6-((R)-1-(3,5-bis(trifluoromethyl)phen...)
Affinity DataIC50: 2.5nMAssay Description:Displacement of [125I]substance P from human NK1 receptor expressed in CHO cells in the presence of 50 percent human serumMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2010
Entry Details Article
PubMed
TargetSubstance-P receptor(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50313628((6R,7S,7aS)-6-((R)-1-(3,5-bis(trifluoromethyl)phen...)
Affinity DataIC50: 2.5nMAssay Description:Displacement of [125I]substance P from human NK1 receptor expressed in CHO cells in the presence of 50 percent human serumMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2010
Entry Details Article
PubMed