BDBM50314225 (R)-4-acetamido-2-(biphenyl-4-ylsulfonamido)-N-hydroxybutanamide::CHEMBL1090647

SMILES CC(=O)NCC[C@@H](NS(=O)(=O)c1ccc(cc1)-c1ccccc1)C(=O)NO

InChI Key InChIKey=RLHOCYLKSSHKMW-UHFFFAOYSA-N

Data  9 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 9 hits for monomerid = 50314225   

TargetMatrix metalloproteinase-14(Human)
University of Pisa

Curated by ChEMBL
LigandPNGBDBM50314225((R)-4-acetamido-2-(biphenyl-4-ylsulfonamido)-N-hyd...)
Affinity DataIC50: 34nMAssay Description:Inhibition of human recombinant MMP14 by fluorometric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2010
Entry Details Article
PubMed
TargetMatrix metalloproteinase-9(Human)
University of Pisa

Curated by ChEMBL
LigandPNGBDBM50314225((R)-4-acetamido-2-(biphenyl-4-ylsulfonamido)-N-hyd...)
Affinity DataIC50: 8.60nMAssay Description:Inhibition of MMP9 by fluorometric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2010
Entry Details Article
PubMed
TargetInterstitial collagenase(Human)
University of Pisa

Curated by ChEMBL
LigandPNGBDBM50314225((R)-4-acetamido-2-(biphenyl-4-ylsulfonamido)-N-hyd...)
Affinity DataIC50: 196nMAssay Description:Inhibition of MMP1 by fluorometric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2010
Entry Details Article
PubMed
Target72 kDa type IV collagenase(Human)
University of Pisa

Curated by ChEMBL
LigandPNGBDBM50314225((R)-4-acetamido-2-(biphenyl-4-ylsulfonamido)-N-hyd...)
Affinity DataIC50: 0.700nMAssay Description:Inhibition of MMP2 by fluorometric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2010
Entry Details Article
PubMed
LigandPNGBDBM50314225((R)-4-acetamido-2-(biphenyl-4-ylsulfonamido)-N-hyd...)
Affinity DataIC50: 300nMAssay Description:Inhibition of human recombinant ADAM17 by fluorometric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2010
Entry Details Article
PubMed
TargetMatrix metalloproteinase-9(Human)
University of Pisa

Curated by ChEMBL
LigandPNGBDBM50314225((R)-4-acetamido-2-(biphenyl-4-ylsulfonamido)-N-hyd...)
Affinity DataIC50: 8.60nMAssay Description:Inhibition of recombinant human proMMP9 using Mca-Lys-Pro-Leu-Gly-Leu-Dap(Dnp)-Ala-Arg-NH2 as substrate preincubated for 3 hrs followed by substrate ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2021
Entry Details Article
PubMed
Target72 kDa type IV collagenase(Human)
University of Pisa

Curated by ChEMBL
LigandPNGBDBM50314225((R)-4-acetamido-2-(biphenyl-4-ylsulfonamido)-N-hyd...)
Affinity DataIC50: 0.700nMAssay Description:Inhibition of recombinant human proMMP2 using Mca-Lys-Pro-Leu-Gly-Leu-Dap(Dnp)-Ala-Arg-NH2 as substrate preincubated for 3 hrs followed by substrate ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2021
Entry Details Article
PubMed
TargetMatrix metalloproteinase-14(Human)
University of Pisa

Curated by ChEMBL
LigandPNGBDBM50314225((R)-4-acetamido-2-(biphenyl-4-ylsulfonamido)-N-hyd...)
Affinity DataIC50: 34nMAssay Description:Inhibition of recombinant human MT1-MMP catalytic domain using Mca-Lys-Pro-Leu-Gly-Leu-Dap(Dnp)-Ala-Arg-NH2 as substrate preincubated for 3 hrs follo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2021
Entry Details Article
PubMed
TargetInterstitial collagenase(Human)
University of Pisa

Curated by ChEMBL
LigandPNGBDBM50314225((R)-4-acetamido-2-(biphenyl-4-ylsulfonamido)-N-hyd...)
Affinity DataIC50: 196nMAssay Description:Inhibition of recombinant human pro-MMP1 using Mca-Lys-Pro-Leu-Gly-Leu-Dap(Dnp)-Ala-Arg-NH2 as substrate preincubated for 3 hrs followed by substrate...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2021
Entry Details Article
PubMed