BDBM50314631 CHEMBL1088949::N-hydroxy-3-(2-(2-(2-methyl-1H-indol-3-yl)ethyl)isoindolin-5-yl)acrylamide

SMILES Cc1[nH]c2ccccc2c1CCN1Cc2ccc(\C=C\C(=O)NO)cc2C1

InChI Key InChIKey=BHTGEWHBEIZLOP-UHFFFAOYSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50314631   

TargetPotassium voltage-gated channel subfamily H member 2(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50314631(N-hydroxy-3-(2-(2-(2-methyl-1H-indol-3-yl)ethyl)is...)
Affinity DataIC50: 4.80E+3nMAssay Description:Inhibition of human ERG expressed in CHO cells by automated patch clamp electrophysiology assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2010
Entry Details Article
PubMed
TargetHistone deacetylase 1(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50314631(N-hydroxy-3-(2-(2-(2-methyl-1H-indol-3-yl)ethyl)is...)
Affinity DataIC50: 27nMAssay Description:Inhibition of FLAG-tagged HDAC1 expressed in HEK293 cells by fluorescent assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2010
Entry Details Article
PubMed
TargetHistone deacetylase 1(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50314631(N-hydroxy-3-(2-(2-(2-methyl-1H-indol-3-yl)ethyl)is...)
Affinity DataIC50: 26nMAssay Description:Inhibition of purified recombinant HDAC1More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2012
Entry Details Article
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50314631(N-hydroxy-3-(2-(2-(2-methyl-1H-indol-3-yl)ethyl)is...)
Affinity DataIC50: 4.80E+3nMAssay Description:Inhibition of human ERG by automated patch clamp assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2012
Entry Details Article
PubMed
TargetCytochrome P450 3A4(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50314631(N-hydroxy-3-(2-(2-(2-methyl-1H-indol-3-yl)ethyl)is...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of CYP3A4More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2012
Entry Details Article
PubMed