BDBM50314643 (E)-3-{4-[(S)-3-(2-tert-Butyl-1H-indol-3-yl)piperidin-1-ylmethyl]-3-fluorophenyl}-N-hydroxyacrylamide::CHEMBL1093335

SMILES CC(C)(C)c1[nH]c2ccccc2c1[C@@H]1CCCN(Cc2ccc(\C=C\C(=O)NO)cc2F)C1

InChI Key InChIKey=ILQPFWGPYWQTHJ-UHFFFAOYSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50314643   

TargetHistone deacetylase 1(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50314643((E)-3-{4-[(S)-3-(2-tert-Butyl-1H-indol-3-yl)piperi...)
Affinity DataIC50: 15nMAssay Description:Inhibition of FLAG-tagged HDAC1 expressed in HEK293 cells by fluorescent assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2010
Entry Details Article
PubMed
TargetHistone deacetylase 3(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50314643((E)-3-{4-[(S)-3-(2-tert-Butyl-1H-indol-3-yl)piperi...)
Affinity DataIC50: 21nMAssay Description:Inhibition of FLAG-tagged HDAC3 expressed in HEK293 cells by fluorescent assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2010
Entry Details Article
PubMed
TargetHistone deacetylase 4(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50314643((E)-3-{4-[(S)-3-(2-tert-Butyl-1H-indol-3-yl)piperi...)
Affinity DataIC50: 38nMAssay Description:Inhibition of HDAC4 expressed in baculovirus system by fluorescent assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2010
Entry Details Article
PubMed
TargetHistone deacetylase 2(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50314643((E)-3-{4-[(S)-3-(2-tert-Butyl-1H-indol-3-yl)piperi...)
Affinity DataIC50: 48nMAssay Description:Inhibition of HDAC2 expressed in baculovirus system by fluorescent assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2010
Entry Details Article
PubMed
TargetHistone deacetylase 6(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50314643((E)-3-{4-[(S)-3-(2-tert-Butyl-1H-indol-3-yl)piperi...)
Affinity DataIC50: 110nMAssay Description:Inhibition of FLAG-tagged HDAC6 expressed in HEK293 cells by fluorescent assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2010
Entry Details Article
PubMed
TargetHistone deacetylase 8(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50314643((E)-3-{4-[(S)-3-(2-tert-Butyl-1H-indol-3-yl)piperi...)
Affinity DataIC50: 364nMAssay Description:Inhibition of HDAC8 expressed in baculovirus system by fluorescent assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2010
Entry Details Article
PubMed