BDBM50315234 (2-methyl-4-(8-(3-methyl-4-(morpholinomethyl)phenyl)quinoxalin-2-yl)phenyl)(morpholino)methanone::CHEMBL1089815

SMILES Cc1cc(ccc1CN1CCOCC1)-c1cccc2ncc(nc12)-c1ccc(C(=O)N2CCOCC2)c(C)c1

InChI Key InChIKey=QTMBJAFKWNRRDA-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50315234   

TargetNon-receptor tyrosine-protein kinase TYK2(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50315234((2-methyl-4-(8-(3-methyl-4-(morpholinomethyl)pheny...)
Affinity DataIC50: 439nMAssay Description:Inhibition of recombinant GST tagged TYK2 protein after 60 mins using FITC-Ahx-KKSRGDYMTMQIG-NH2 substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2010
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK1(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50315234((2-methyl-4-(8-(3-methyl-4-(morpholinomethyl)pheny...)
Affinity DataIC50: 362nMAssay Description:Inhibition of recombinant GST tagged JAK1 protein after 60 mins using FITC-Ahx-KKSRGDYMTMQIG-NH2 substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2010
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK2(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50315234((2-methyl-4-(8-(3-methyl-4-(morpholinomethyl)pheny...)
Affinity DataIC50: 13nMAssay Description:Inhibition of recombinant GST tagged JAK2 protein after 60 mins using FITC-GGEEEEYFELVKKKK-NH2 substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2010
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK3(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50315234((2-methyl-4-(8-(3-methyl-4-(morpholinomethyl)pheny...)
Affinity DataIC50: 408nMAssay Description:Inhibition of recombinant GST tagged JAK3 protein after 60 mins using FITC-GGEEEEYFELVKKKK-NH2 substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2010
Entry Details Article
PubMed