BDBM50315243 2-(4-(7-fluoro-3-(3,4,5-trimethoxyphenyl)quinoxalin-5-yl)phenyl)-1-morpholinoethanone::CHEMBL1091191

SMILES COc1cc(cc(OC)c1OC)-c1cnc2cc(F)cc(-c3ccc(CC(=O)N4CCOCC4)cc3)c2n1

InChI Key InChIKey=JAWKHVZHKTWGST-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50315243   

TargetTyrosine-protein kinase JAK1(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50315243(2-(4-(7-fluoro-3-(3,4,5-trimethoxyphenyl)quinoxali...)
Affinity DataIC50: 940nMAssay Description:Inhibition of recombinant GST tagged JAK1 protein after 60 mins using FITC-Ahx-KKSRGDYMTMQIG-NH2 substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2010
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK2(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50315243(2-(4-(7-fluoro-3-(3,4,5-trimethoxyphenyl)quinoxali...)
Affinity DataIC50: 101nMAssay Description:Inhibition of recombinant GST tagged JAK2 protein after 60 mins using FITC-GGEEEEYFELVKKKK-NH2 substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2010
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK3(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50315243(2-(4-(7-fluoro-3-(3,4,5-trimethoxyphenyl)quinoxali...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of recombinant GST tagged JAK3 protein after 60 mins using FITC-GGEEEEYFELVKKKK-NH2 substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2010
Entry Details Article
PubMed
TargetNon-receptor tyrosine-protein kinase TYK2(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50315243(2-(4-(7-fluoro-3-(3,4,5-trimethoxyphenyl)quinoxali...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of recombinant GST tagged TYK2 protein after 60 mins using FITC-Ahx-KKSRGDYMTMQIG-NH2 substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2010
Entry Details Article
PubMed