BDBM50316259 CHEMBL1097942::isopropyl 4-(6-{4-[(cyclopropylcarbamoyl)amino]phenyl}-4-morpholin-4-yl-1Hpyrazolo[3,4-d]pyrimidin-1-yl)piperidine-1-carboxylate

SMILES CC(C)OC(=O)N1CCC(CC1)n1ncc2c(nc(nc12)-c1ccc(NC(=O)NC2CC2)cc1)N1CCOCC1

InChI Key InChIKey=OTEZFXTVGGVQLS-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50316259   

TargetSerine/threonine-protein kinase mTOR(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50316259(isopropyl 4-(6-{4-[(cyclopropylcarbamoyl)amino]phe...)
Affinity DataIC50: 0.5nMAssay Description:Inhibition of human mTOR (1360-2549 amino acids) expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/19/2010
Entry Details Article
PubMed
LigandPNGBDBM50316259(isopropyl 4-(6-{4-[(cyclopropylcarbamoyl)amino]phe...)
Affinity DataIC50: 1.78E+3nMAssay Description:Inhibition of PI3Kalpha by DELFIA assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/19/2010
Entry Details Article
PubMed
LigandPNGBDBM50316259(isopropyl 4-(6-{4-[(cyclopropylcarbamoyl)amino]phe...)
Affinity DataIC50: 3.55E+3nMAssay Description:Inhibition of PI3Kgamma by DELFIA assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/19/2010
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase ATR(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50316259(isopropyl 4-(6-{4-[(cyclopropylcarbamoyl)amino]phe...)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of ATR by DELFIA assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/19/2010
Entry Details Article
PubMed