BDBM50317699 (4-cyclobutyl-1,4-diazepan-1-yl)((2R,4S)-4-(3-fluorophenoxy)pyrrolidin-2-yl)methanone::CHEMBL1095845

SMILES Fc1cccc(O[C@@H]2CN[C@H](C2)C(=O)N2CCCN(CC2)C2CCC2)c1

InChI Key InChIKey=XAQNCLSQQYEQMI-UHFFFAOYSA-N

Data  1 KI  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50317699   

TargetPotassium voltage-gated channel subfamily H member 2(Human)
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50317699((4-cyclobutyl-1,4-diazepan-1-yl)((2R,4S)-4-(3-fluo...)
Affinity DataIC50: 3.00E+3nMAssay Description:Inhibition of human ERG by patch clamp assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/19/2010
Entry Details Article
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50317699((4-cyclobutyl-1,4-diazepan-1-yl)((2R,4S)-4-(3-fluo...)
Affinity DataIC50: 1.00E+4nMAssay Description:Displacement of labeled dofetilide human ERGMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/19/2010
Entry Details Article
PubMed
TargetHistamine H3 receptor(Human)
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50317699((4-cyclobutyl-1,4-diazepan-1-yl)((2R,4S)-4-(3-fluo...)
Affinity DataKi:  3.40nMAssay Description:Binding affinity to human histamine H3 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/19/2010
Entry Details Article
PubMed