BDBM50317705 4-((3S,5R)-5-(4-cyclopentyl-1,4-diazepane-1-carbonyl)pyrrolidin-3-yloxy)benzonitrile::CHEMBL1097883

SMILES O=C([C@H]1C[C@@H](CN1)Oc1ccc(cc1)C#N)N1CCCN(CC1)C1CCCC1

InChI Key InChIKey=DZMJATAIFBTELK-UHFFFAOYSA-N

Data  2 KI  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50317705   

TargetPotassium voltage-gated channel subfamily H member 2(Human)
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50317705(4-((3S,5R)-5-(4-cyclopentyl-1,4-diazepane-1-carbon...)
Affinity DataIC50: 2.90E+3nMAssay Description:Displacement of labeled dofetilide human ERGMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/19/2010
Entry Details Article
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50317705(4-((3S,5R)-5-(4-cyclopentyl-1,4-diazepane-1-carbon...)
Affinity DataIC50: 2.90E+3nMAssay Description:Displacement of [3H]dofetilide from human recombinant ERG by Competitive binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2012
Entry Details Article
PubMed
TargetHistamine H3 receptor(Human)
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50317705(4-((3S,5R)-5-(4-cyclopentyl-1,4-diazepane-1-carbon...)
Affinity DataKi:  3.20nMAssay Description:Binding affinity to human histamine H3 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/19/2010
Entry Details Article
PubMed
TargetHistamine H3 receptor(Human)
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50317705(4-((3S,5R)-5-(4-cyclopentyl-1,4-diazepane-1-carbon...)
Affinity DataKi:  4nMAssay Description:Displacement of [125I]Iodoproxyfan from human recombinant histamine H3 receptor by Competitive binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2012
Entry Details Article
PubMed