BDBM50318596 3-((4-(6-Bromo-2-(4-(4-methylpiperazin-1-yl)phenyl)-3H-imidazo-[4,5-b]pyridin-7-yl)piperazin-1-yl)methyl)-5-methylisoxazole::CHEMBL1086579

SMILES CN1CCN(CC1)c1nc2ncc(Br)c(N3CCN(Cc4cc(C)on4)CC3)c2[nH]1

InChI Key InChIKey=FZTUPODAEPTYNG-UHFFFAOYSA-N

Data  10 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 10 hits for monomerid = 50318596   

TargetAurora kinase B(Human)
The Institute of Cancer Research

Curated by ChEMBL
LigandPNGBDBM50318596(3-((4-(6-Bromo-2-(4-(4-methylpiperazin-1-yl)phenyl...)
Affinity DataIC50: 25nMAssay Description:Inhibition of human recombinant Aurora B expressed in baculovirus systemMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/31/2012
Entry Details Article
PubMed
TargetCytochrome P450 2A6(Human)
The Institute of Cancer Research

Curated by ChEMBL
LigandPNGBDBM50318596(3-((4-(6-Bromo-2-(4-(4-methylpiperazin-1-yl)phenyl...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of CYP2A6 from human liver microsome by LC-MS/MS analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/31/2012
Entry Details Article
PubMed
TargetAurora kinase C(Human)
The Institute of Cancer Research

Curated by ChEMBL
LigandPNGBDBM50318596(3-((4-(6-Bromo-2-(4-(4-methylpiperazin-1-yl)phenyl...)
Affinity DataIC50: 19nMAssay Description:Inhibition of human recombinant Aurora C expressed in baculovirus systemMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/31/2012
Entry Details Article
PubMed
TargetCytochrome P450 1A2(Human)
The Institute of Cancer Research

Curated by ChEMBL
LigandPNGBDBM50318596(3-((4-(6-Bromo-2-(4-(4-methylpiperazin-1-yl)phenyl...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of CYP1A2 from human liver microsome by LC-MS/MS analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/31/2012
Entry Details Article
PubMed
TargetCytochrome P450 2C9(Human)
The Institute of Cancer Research

Curated by ChEMBL
LigandPNGBDBM50318596(3-((4-(6-Bromo-2-(4-(4-methylpiperazin-1-yl)phenyl...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of CYP2C9 from human liver microsome by LC-MS/MS analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/31/2012
Entry Details Article
PubMed
TargetCytochrome P450 2C19(Human)
The Institute of Cancer Research

Curated by ChEMBL
LigandPNGBDBM50318596(3-((4-(6-Bromo-2-(4-(4-methylpiperazin-1-yl)phenyl...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of CYP2C19 from human liver microsome by LC-MS/MS analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/31/2012
Entry Details Article
PubMed
TargetCytochrome P450 2D6(Human)
The Institute of Cancer Research

Curated by ChEMBL
LigandPNGBDBM50318596(3-((4-(6-Bromo-2-(4-(4-methylpiperazin-1-yl)phenyl...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of CYP2D6 from human liver microsome by LC-MS/MS analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/31/2012
Entry Details Article
PubMed
TargetCytochrome P450 3A4(Human)
The Institute of Cancer Research

Curated by ChEMBL
LigandPNGBDBM50318596(3-((4-(6-Bromo-2-(4-(4-methylpiperazin-1-yl)phenyl...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of CYP3A4 from human liver microsome by LC-MS/MS analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/31/2012
Entry Details Article
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
The Institute of Cancer Research

Curated by ChEMBL
LigandPNGBDBM50318596(3-((4-(6-Bromo-2-(4-(4-methylpiperazin-1-yl)phenyl...)
Affinity DataIC50: 3.00E+3nMAssay Description:Inhibition of human ERGMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/31/2012
Entry Details Article
PubMed
TargetAurora kinase A(Human)
The Institute of Cancer Research

Curated by ChEMBL
LigandPNGBDBM50318596(3-((4-(6-Bromo-2-(4-(4-methylpiperazin-1-yl)phenyl...)
Affinity DataIC50: 15nMAssay Description:Inhibition of human recombinant Aurora A expressed in baculovirus systemMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/31/2012
Entry Details Article
PubMed