BDBM50318870 ((4-(2-(cis-4-aminocyclohexyl)-9-ethyl-9H-purin-6-ylamino)phenyl)(hydroxy)phosphoryl)methylphosphonic acid::2,6,9-Trisubstituted Purine, 8::2,6,9-Trisubstituted Purine, AP23451::CHEMBL1084268

SMILES CCn1cnc2c(Nc3ccc(cc3)P(O)(=O)CP(O)(O)=O)nc(nc12)[C@H]1CC[C@H](N)CC1

InChI Key InChIKey=FGMSUCIOAMNCKF-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50318870   

TargetProto-oncogene tyrosine-protein kinase Src(Mouse)
Ariad Pharmaceuticals

LigandPNGBDBM50318870(2,6,9-Trisubstituted Purine, AP23451 | 2,6,9-Trisu...)
Affinity DataIC50: 68nMAssay Description:2,6,9-Trisubstituted purines were evaluated for their src kinase inhibitory activities using an ELISA assay.More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/31/2011
Entry Details Article
PubMed
TargetProto-oncogene tyrosine-protein kinase Src(Mouse)
Ariad Pharmaceuticals

LigandPNGBDBM50318870(2,6,9-Trisubstituted Purine, AP23451 | 2,6,9-Trisu...)
Affinity DataIC50: 273nMAssay Description:2,6,9-Trisubstituted purines were evaluated for their src kinase inhibitory activities using an ELISA assay.More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/31/2011
Entry Details Article
PubMed
TargetTyrosine-protein kinase ABL1(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50318870(2,6,9-Trisubstituted Purine, AP23451 | 2,6,9-Trisu...)
Affinity DataIC50: 68nMAssay Description:Inhibition of ABL1More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2010
Entry Details Article
PubMed
LigandPNGBDBM50318870(2,6,9-Trisubstituted Purine, AP23451 | 2,6,9-Trisu...)
Affinity DataIC50: 68nMAssay Description:Inhibition of SRCMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2010
Entry Details Article
PubMed