BDBM50319622 CHEMBL1083152::N,4-Dimethyl-5-(2-(3,4,5-trimethoxyphenylamino)pyrimidin-4-yl)thiazol-2-amine

SMILES CNc1nc(C)c(s1)-c1ccnc(Nc2cc(OC)c(OC)c(OC)c2)n1

InChI Key InChIKey=OTACRQCAOBRLAZ-UHFFFAOYSA-N

Data  7 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 50319622   

TargetAurora kinase A(Human)
Cyclacel

Curated by ChEMBL
LigandPNGBDBM50319622(N,4-Dimethyl-5-(2-(3,4,5-trimethoxyphenylamino)pyr...)
Affinity DataKi:  1nMAssay Description:Inhibition of human recombinant Aurora A after 30 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2010
Entry Details Article
PubMed
TargetAurora kinase B(Human)
Cyclacel

Curated by ChEMBL
LigandPNGBDBM50319622(N,4-Dimethyl-5-(2-(3,4,5-trimethoxyphenylamino)pyr...)
Affinity DataKi:  3nMAssay Description:Inhibition of human recombinant Aurora B after 60 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2010
Entry Details Article
PubMed
TargetCyclin-dependent kinase 9(Human)
Cyclacel

Curated by ChEMBL
LigandPNGBDBM50319622(N,4-Dimethyl-5-(2-(3,4,5-trimethoxyphenylamino)pyr...)
Affinity DataKi:  6nMAssay Description:Inhibition of CDK9More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2010
Entry Details Article
PubMed
TargetCyclin-dependent kinase 2(Human)
Cyclacel

Curated by ChEMBL
LigandPNGBDBM50319622(N,4-Dimethyl-5-(2-(3,4,5-trimethoxyphenylamino)pyr...)
Affinity DataKi:  256nMAssay Description:Inhibition of CDK2More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2010
Entry Details Article
PubMed
TargetCyclin-dependent kinase 1(Human)
Cyclacel

Curated by ChEMBL
LigandPNGBDBM50319622(N,4-Dimethyl-5-(2-(3,4,5-trimethoxyphenylamino)pyr...)
Affinity DataKi:  367nMAssay Description:Inhibition of CDK1More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2010
Entry Details Article
PubMed
TargetCyclin-dependent kinase 7(Human)
Cyclacel

Curated by ChEMBL
LigandPNGBDBM50319622(N,4-Dimethyl-5-(2-(3,4,5-trimethoxyphenylamino)pyr...)
Affinity DataKi:  370nMAssay Description:Inhibition of CDK7More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2010
Entry Details Article
PubMed
TargetCyclin-dependent kinase 4(Human)
Cyclacel

Curated by ChEMBL
LigandPNGBDBM50319622(N,4-Dimethyl-5-(2-(3,4,5-trimethoxyphenylamino)pyr...)
Affinity DataKi:  955nMAssay Description:Inhibition of CDK4More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2010
Entry Details Article
PubMed