BDBM50320216 CHEMBL1083644::isobutyl4-(7-amino-3-(3-(piperazin-1-yl)phenyl)pyrazolo[1,5-a]pyrimidin-6-yl)phenylcarbamate

SMILES CC(C)COC(=O)Nc1ccc(cc1)-c1cnc2c(cnn2c1N)-c1cccc(c1)N1CCNCC1

InChI Key InChIKey=PDQSBODXIIIHSM-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50320216   

TargetTyrosine-protein kinase Lck(Human)
Novartis Institute of Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50320216(isobutyl4-(7-amino-3-(3-(piperazin-1-yl)phenyl)pyr...)
Affinity DataIC50: 7nMAssay Description:Inhibition of LCK in human Jurkat cells assessed as ZAP70 phosphorylation by FACS assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2010
Entry Details Article
PubMed
TargetTyrosine-protein kinase HCK(Human)
Novartis Institute of Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50320216(isobutyl4-(7-amino-3-(3-(piperazin-1-yl)phenyl)pyr...)
Affinity DataIC50: 310nMAssay Description:Inhibition of HCKMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2010
Entry Details Article
PubMed
TargetProto-oncogene tyrosine-protein kinase Src(Human)
Novartis Institute of Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50320216(isobutyl4-(7-amino-3-(3-(piperazin-1-yl)phenyl)pyr...)
Affinity DataIC50: 642nMAssay Description:Inhibition of SRCMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2010
Entry Details Article
PubMed
TargetVascular endothelial growth factor receptor 2(Human)
Novartis Institute of Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50320216(isobutyl4-(7-amino-3-(3-(piperazin-1-yl)phenyl)pyr...)
Affinity DataIC50: 2.10E+3nMAssay Description:Inhibition of KDRMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2010
Entry Details Article
PubMed